The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish

Yi, Jia; Ma, Yilei; Ruan, Jing; You, Si; Ma, Jiahui; Yu, Haiyang; Zhao, Jing; Zhang, Kun; Yang, Qinsi; Jin, Libo; Zeng, Guoming; Sun, Da

doi:10.1016/j.envint.2024.108432

Cited by 2 publications

(2 citation statements)

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“…They may produce oxidative stress through ROS, triggering biological responses detrimental to reproductive health, including inflammation, apoptosis, and signaling pathways induced by oxidative stress. MNPs can cause oxidative stress in zebrafish ovarian cells, increase DNA damage, and induce an increase in apoptosis in genes associated with vitellogenesis [ 47 , 121 ]. Additionally, MNPs significantly upregulate proinflammatory genes (NFκβ and TNF-α), affecting the normal ovulation process.…”

Section: Effects Of Mnps On the Reproductive System Of Zebrafishmentioning

confidence: 99%

“…The sociological behavior of zebrafish mirrors that of humans, making behavioral studies relevant to assess the effects of chemicals on reproductive behavior and fertility in both animals and humans [ 45 ]. The current reproductive toxicity studies of MNPs in zebrafish follow the classical endocrine disruptor model, characterized by changes in fecundity, oviposition success, and hypothalamic–pituitary–gonadal (HPG) axis responses [ 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

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Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Wu,

Yu,

et al. 2024

Toxics

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The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior and reproductive health of aquatic organisms while posing potential risks to human health and ecosystems. This review focuses on the neurobehavioral changes and reproductive toxicity of MNPs in zebrafish and their relationships. At the same time, the neurobehavioral changes caused by MNPs were studied, and the synergistic effects of the interaction of these pollutants with other environmental contaminants were explored. In addition, zebrafish, as a model organism, provide valuable insights into the subtle but important effects of MNPs on reproductive behavior, which is critical for understanding reproductive success, suggesting that behavioral changes can serve as an early biomarker of reproductive toxicity. In addition, based on classical endocrine disruptor models and behavioral research methods, the current status of the research on the reproductive toxicity of MNPs in zebrafish was reviewed, which further indicated that the behavioral parameters of zebrafish can be used as an effective and rapid tool to evaluate the reproductive toxicity of MNPs. However, behavioral methods for rapidly assessing the toxicity of MNPs are still an area of exploration. To address limitations and challenges in the current scope of research, this review outlines future research directions with the aim of improving our understanding of the environmental and health impacts of MNPs. This work aims to inform targeted environmental policies and advance public health strategies to address the growing challenge of MNPs pollution.

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Section: Effects Of Mnps On the Reproductive System Of Zebrafishmentioning

confidence: 99%