The Investigation of Physical Mechanism of Transcapillary Exchange by Phase-Sensitive Laser Method

Bagayev, S.N.; Zakharov, V.N.; Orlov, V.A.; Panov, S. V.; Fomin, Yu. N.

doi:10.1109/apeie.2006.4292385

Cited by 3 publications

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“…2). In addition, contractions of smooth muscle cells of microcapillaries occur with a high frequency, leading to radial mechanical displacements of the microvessels walls [32,42,43]. There are the conditions for the membrane to shrink to a critical value ∆, the kinks-solitons begin to run along the hydrocarbon tails of phospholipids, moving gas molecules with their bends.…”

Section: Discussion Of the Obtained Results And Concluding Remarksmentioning

confidence: 99%

Mechanism of gas molecule transport through erythrocytes’ membranes by kinks-solitons

Мокрушников¹,

Rudyak²,

Lezhnev³

2021

Nanosystems: Phys. Chem. Math.

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A model of kinks appearance in the lipid bilayer membrane of erythrocytes, which are responsible for gas molecule transport, in particular, oxygen, is proposed. It was shown that the kinks arise due to the simultaneous action of transverse and tensile longitudinal mechanical stresses compressing the membrane. This model explains the membrane's permeability sharp increase for gases during an erythrocyte passage through the microcapillary network with the compressive transverse mechanical stresses sharply increasing in its membrane. It was found that the equation of kinks motion has a soliton solution, so that a kink-soliton is formed in the bilayer of the erythrocyte membrane. The developed model is consistent with the previously experimentally established fact that the native erythrocyte membranes in the bloodstream undergo a structural transition, when small changes in blood pH, hormone concentration, and temperature dramatically change the conformation of the biomembranes and its functions by changing the mechanical stress field in the biomembrane.

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Section: Discussion Of the Obtained Results And Concluding Remarksmentioning

confidence: 99%

Mechanism of gas molecule transport through erythrocytes’ membranes by kinks-solitons

Мокрушников¹,

Rudyak²,

Lezhnev³

2021

Nanosystems: Phys. Chem. Math.

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“…В капиллярах же большего диаметра пульсации скорости зарегистрированы методами прямых измерений скорости кровотока в капиллярах в экспериментах [3,4]. Имеются также данные экспериментальных исследований [5,6], подтверждающие наличие механических перемещений стенок микрососудов (изменений просвета), связанных с ритмом сердечных сокращений. Теоретическое описание течений в ячейках кровеносных систем проводилось в работах [7,8] на основе развитой авторами математической модели.…”

Section: Introductionunclassified

Modeling of Pulsating Flow in Blood Capillaries

Khmel¹

2013

Math.Biol.Bioinf.

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“…The use of the noninvasive phase-sensitive laser method in investigating the biomechanics of the microhemocirculation link has made it possible to reveal for the first time the presence of fast (at frequencies of up to 1 kHz) local shifts of arteriole and venule walls [4]. It has been established that the width of the spectral range of observed transverse vibrations caused, as it turned out, by the contraction of smooth muscular cells, depends linearly on the blood flow velocity in them [5].…”

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confidence: 99%

“…It has been established that the width of the spectral range of observed transverse vibrations caused, as it turned out, by the contraction of smooth muscular cells, depends linearly on the blood flow velocity in them [5]. Attempts to explain the active role of microvessels in the microhemocirculation biomechanics led us to the idea that there is a relation between the registered mechanical vibrations and the electrical processes in myocytes.…”

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confidence: 99%

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Experimental and theoretical studies of the influence of pulse pressure oscillations on the processes of microhemocirculation

Bagayev

Zakharov

Orlov

et al. 2012

J Eng Phys Thermophy

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UDC 532.546The influence of pulse pressure oscillations on the processes of transcapillary exchange in the hemodynamics has been investigated by experimental and numerical methods. The active role of microvessel walls in the mass transfer has been confirmed. On the basis of the generalized nonstationary Starling scheme patterns of transcapillary exchange with alternation of the filtration and reabsorption processes have been determined. Flows in the interstitial space have been modeled numerically. It has been established that the presence of pulsations promotes enhancement of the transcapillary exchange.

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The Investigation of Physical Mechanism of Transcapillary Exchange by Phase-Sensitive Laser Method

Cited by 3 publications

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Mechanism of gas molecule transport through erythrocytes’ membranes by kinks-solitons

Mechanism of gas molecule transport through erythrocytes’ membranes by kinks-solitons

Modeling of Pulsating Flow in Blood Capillaries

Experimental and theoretical studies of the influence of pulse pressure oscillations on the processes of microhemocirculation

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