The investigation of neonatal MK-801 administration and physical environmental enrichment on emotional and cognitive functions in adult Balb/c mice

Akıllıoğlu, Kübra; Melik, Emine Babar; Melik, Enver; Kocahan, Sayad

doi:10.1016/j.pbb.2012.06.006

Cited by 19 publications

(9 citation statements)

References 60 publications

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“…Our data also extended the existing literature on the behavioral effects of postweaning EE documented in WT mice. The anxiogenic effects of EE in WT mice here are consistent with the previous findings in our (Pietropaolo et al, 2006;Zhu et al, 2006) and other laboratories (Abramov, Puussaar, Raud, Kurrikoff, & Vasar, 2008;Pietropaolo et al, 2004;van de Weerd, Baumans, Koolhaas, & van Zutphen, 1994), although some reports have demonstrated an opposite effect, or no effect, of EE in mice (Abramov et al, 2008;Akillioglu, Babar Melik, Melik, & Kocahan, 2012;Chapillon, Manneche, Belzung, & Caston, 1999;Chapillon, Patin, Roy, Vincent, & Caston, 2002;Roy, Belzung, Delarue, & Chapillon, 2001). This apparent inconsistency might in parts be attributed to the type of anxiety tests and the mouse strain employed.…”

Section: Discussionsupporting

confidence: 92%

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease

Pietropaolo

Feldon

Yee

2014

Cogn Affect Behav Neurosci

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Although the impacts of environmental enrichment (EE) in several genetic models of Alzheimer's disease (AD) have been documented, the focus has remained predominantly on cognition. Few have investigated the expression of emotional phenotypes that mimic the notable affective features in AD. Here, we studied the interaction between EE and the coexpression of three genetic risk factors (mutations) for AD. In a longitudinal design, 3×Tg-AD mutants and wild type controls were compared at 6-7 months and subsequently at 12-13 months of age. Under standard housing, phenotypes of heightened anxiety levels were identified in the 3×Tg-AD mice in the elevated plus maze and open-field tests. Such trait differences between genotypes were substantially diminished under EE housing, which was attributable to the anxiolytic impact of EE on the mutant mice as much as the anxiogenic impact of EE on the wild type mice. In contrast, the phenotypes in learned fear were not significantly modified by EE in the tests of Pavlovian freezing and conditioned active avoidance conducted at either age. Rearing under EE thus has uncovered a novel distinction between innate and acquired expressions of fear response in the 3×Tg-AD mouse model that might be relevant to the mental health management of AD.

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Section: Discussionsupporting

confidence: 92%

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease

Pietropaolo

Feldon

Yee

2014

Cogn Affect Behav Neurosci

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“…It is reported that treatment with NMDA receptor antagonists during early developmental stages leads to an increase both in locomotor activity and exploratory behaviors [18][19][20]; however, in our study there was a decrease in the locomotor activity and exploratory behaviors. Our previous study also showed decreases in adult locomotor activity and exploratory behavior [21,22]. Studies report that there are continuous interactions between the dopaminergic and the NMDA pathways.…”

Section: Discussionsupporting

confidence: 55%

Effect of clozapine on locomotor activity and anxiety-related behavior in the neonatal mice administered MK-801

Pınar

Akıllıoğlu

Sefil

et al. 2015

Bosn J of Basic Med Sci

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Atypical antipsychotics have been used to treat fear and anxiety disturbance that are highly common in schizophrenic patients. It is suggested that disruptions of N-methyl-d-aspartate (NMDA)-mediated transmission of glutamate may underlie the pathophysiology of schizophrenia. The present study was conducted to analyze the effectiveness of clozapine on the anxiety-related behavior and locomotor function of the adult brain, which had previously undergone NMDA receptor blockade during a developmental period. In order to block the NMDA receptor, male mice were administered 0.25 mg/kg of MK-801 on days 7 to 10 postnatal. In adulthood, they were administered intraperitoneally 0.5 mg/kg of clozapine and tested with open-field and elevated plus maze test, to assess their emotional behavior and locomotor activity. In the group receiving MK-801 in the early developmental period the elevated plus maze test revealed a reduction in the anxiety-related behavior (p<0.05), while the open-field test indicated a decrease in locomotor activity (p<0.01). Despite these reductions, clozapine could not reverse the NMDA receptor blockade. Also, as an atypical antipsychotic agent, clozapine could not reverse impairment in the locomotor activity and anxiety-related behavior, induced by administration of the MK-801 in neonatal period.

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“…To our knowledge, this is one of the first studies to have evaluated both cognitive performance as well as social interactions in NMRI mice exposed to EE. Until now, no study has addressed the role of EE in both social interaction and learning tasks, which have been evaluated separately, although recent evidence suggests that emotional and cognitive changes can be observed in the same group of animals exposed to EE conditions (Akillioglu, Babar Melik, Melik, & Kocahan, ).…”

Section: Discussionmentioning

confidence: 99%

Environmental Enrichment Improves Novel Object Recognition and Enhances Agonistic Behavior in Male Mice

Mesa-Gresa

Pérez-Martínez

Redolat

2013

Aggressive Behavior

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Environmental enrichment (EE) is an experimental paradigm in which rodents are housed in complex environments containing objects that provide stimulation, the effects of which are expected to improve the welfare of these subjects. EE has been shown to considerably improve learning and memory in rodents. However, knowledge about the effects of EE on social interaction is generally limited and rather controversial. Thus, our aim was to evaluate both novel object recognition and agonistic behavior in NMRI mice receiving EE, hypothesizing enhanced cognition and slightly enhanced agonistic interaction upon EE rearing. During a 4-week period half the mice (n = 16) were exposed to EE and the other half (n = 16) remained in a standard environment (SE). On PND 56-57, animals performed the object recognition test, in which recognition memory was measured using a discrimination index. The social interaction test consisted of an encounter between an experimental animal and a standard opponent. Results indicated that EE mice explored the new object for longer periods than SE animals (P < .05). During social encounters, EE mice devoted more time to sociability and agonistic behavior (P < .05) than their non-EE counterparts. In conclusion, EE has been shown to improve object recognition and increase agonistic behavior in adolescent/early adulthood mice. In the future we intend to extend this study on a longitudinal basis in order to assess in more depth the effect of EE and the consistency of the above-mentioned observations in NMRI mice.

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The investigation of neonatal MK-801 administration and physical environmental enrichment on emotional and cognitive functions in adult Balb/c mice

Cited by 19 publications

References 60 publications

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease

Effect of clozapine on locomotor activity and anxiety-related behavior in the neonatal mice administered MK-801

Environmental Enrichment Improves Novel Object Recognition and Enhances Agonistic Behavior in Male Mice

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