The Investigation of Gene Regulation and Variation in Human Cancers and Other Diseases

Tanabe, Shihori; Jee, Sun Ha

doi:10.5772/51271

Cited by 2 publications

(3 citation statements)

References 152 publications

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“…This methodology is a non-selective way of analysis and takes into account a complete spectrum or an image of the test material. Combining analytical techniques with statistical analyses, the fingerprint aims at having a more complete description of the product and can be a tool to help track the path of a product based on its physical and chemical properties [Capuano and Van Ruth 2012].…”

Section: The Processing Of Cocoa Beansmentioning

confidence: 99%

Supply chain and traceability in the processing of cocoa beans

Urbańska¹,

Kowalska²,

Miarka³

2018

Zeszyty Problemowe Postępów Nauk Rolniczych

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Section: The Processing Of Cocoa Beansmentioning

confidence: 99%

Supply chain and traceability in the processing of cocoa beans

Urbańska¹,

Kowalska²,

Miarka³

2018

Zeszyty Problemowe Postępów Nauk Rolniczych

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“…However, convincing evidence shows that genetic factors may play an important role in these diseases [152,153]. Recent GWAS have led to the identification of a series of SNPs that are robustly associated with either the risk of diabetes or cancers [151,[154][155][156][157][158][159].…”

Section: Genetic Risk Score In Cancer and Diabetesmentioning

confidence: 99%

“…For type 2 diabetes mellitus, common SNPs have been identified in the PPARG, KCNJ11, and TCF7L2 genes, and have been widely replicated in populations of various ethnicities [160][161][162]. Other potential new loci include HHEX, CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and WFS1 [65,[155][156][157][158][159]163,164]. A number of SNPs have been identified as associated with breast cancer risk, including FGFR2, CASP8, ERBB4, TAB2, BARX2, TMEM45B, ESR1, FGFR2, TNRC9, MAP3K1, MGC33648, MIER3, and RAD51L1 [74,75,151] (Table 5).…”

Section: Genetic Risk Score In Cancer and Diabetesmentioning

confidence: 99%

Latest Research into Quality Control

Akyar¹

2012

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Additional information is available at the end of the chapter http://dx.doi.org/10.5772/45955. Introduction Worldwide demand of herbal medicines has increased in recent years owing to rising interest in the health benefits. "mong with this, the quality control of plant extracts and plant-derived medicines is growing in importance to ensure their efficacy and safety. Effective quality control of the traditional Chinese medicines TCMM and plant crude extracts requires the rapid and sensitive methods for separation and quantification of bioactive compounds. Various methods have been employed for the separation and quantification of certain constituents in medicinal plants or herbal medicines. However, the current methods in use are not necessarily optimal approaches. For example, separation and quantification of glycyrrhi-zin GCC, the main active constituent in licorice Glycyrrhiza spp.., have been used gas chromatography , high performance liquid chromatography HPLCC and micellar trokinetic chromatography and so on [,,]. Commercial purification of GC typically progressed through several steps, including crystallization, column chromatography, and liquid partitioning. These current methods are not sufficiently approaches because of insufficient sensitivity and reproducibility, large consumption of organic solvent for extraction and analysis, and long analysis time. Immunoassay systems using monoclonal antibody M"bb against drugs and small molecular weight bioactive compounds have become an important tool for studies on receptor binding assays, enzyme assays, and quantitative and qualitative analytical techniques both in vivo and in vitro studies. "lthough immunoaffinity purification against higher molecule analyte such as peptides and proteins are widely used in the research and commercial ways, there are too few cases of immunoaffinity purification targeting a small molecule compound such as natural compounds. Our laboratory has prepared many kinds of M"bs against © 2012 Uto et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. naturally occurring bioactive compounds such as terpenoids [[-], alkaloids [[,,], saponins [[-], and phenolics [[[-], and developed several applications. One of the applications by using M"bs is immunoaffinity column conjugated with anti-natural compound-specific M"bs and work by specifically binding and removing the target compounds. We have been establishing several affinity columns against a kind of terpenoid, forskolin [[[], solasodine glyco-sides [[[], ginsenosides Rb [[[], and GC [[[]. "pplication of an immunoaffinity column to isolate and concentrate a natural compound may decrease the amount of solvent consumption and the number of purification steps, shorten analysis time, and simplify sample analysis compared to traditional cleanup technique...

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The Investigation of Gene Regulation and Variation in Human Cancers and Other Diseases

Cited by 2 publications

References 152 publications

Supply chain and traceability in the processing of cocoa beans

Supply chain and traceability in the processing of cocoa beans

Latest Research into Quality Control

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