The Investigation of Fevers in North Queensland by Mouse Inoculation, With Particular Reference to Scrub Typhus

Carley, J. G.; Doherty, R. L.; Derrick, E. H.; Pope, J. H.; Emanuel, Marie L.; Ross, C J

doi:10.1111/imj.1955.4.2.91

Cited by 23 publications

(9 citation statements)

References 4 publications

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“…We examined 27 isolates collected from patients during an investigation of "pyrexia of unknown origin" cases in North Queensland (Carley et al, 1955). Unfortunately, most of the avirulent strains from the original study have been lost.…”

Section: Methodsmentioning

confidence: 99%

SEROLOGICAL ANALYSIS OF RICKETTSIA TSUTSUGAMUSHI ISOLATES FROM NORTH QUEENSLAND*

Shirai

Campbell

Gan

et al. 1982

Aust J Exp Biol Med

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Summary. Fifty-two Rickettsia tsutsuganwshi isolates from humans, rodents and chiggers in North Queensland were serologically characterized by the direct immunofluorescence test. A majority (71%) of the isolates was a mixture of two or more strains. The most frequently detected strains in the 52 isolates were TA716 (94%), TA763 (42%), TA686 (33%), and Karp (31%). The Gilliam strain was detected in only 4% of the isolates.

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Section: Methodsmentioning

confidence: 99%

SEROLOGICAL ANALYSIS OF RICKETTSIA TSUTSUGAMUSHI ISOLATES FROM NORTH QUEENSLAND*

Shirai

Campbell

Gan

et al. 1982

Aust J Exp Biol Med

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“…Early studies suggested the promise of vaccineinduced heterologous immunity, at least in the guinea pig model. However, cross-immunity can vary tremendously, and general strain relatedness can be shown but not to the extent demonstrated using the various serological tests [24,88,113,114]. In addition, the relative virulence in challenged animals appears to be highly mouse-strain specific [78,79,115].…”

Section: Cfmentioning

confidence: 99%

“…in North Queensland [113,114] were characterized by DFA [122]. Of the isolates, 71% were multiply reactive to as many as 4 conjugates.…”

Section: Geographic Distribution Of Antigenic Typesmentioning

confidence: 99%

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

et al. 2009

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Orientia tsutsugamushi is the etiological agent of scrub typhus, an acute, mite-borne, febrile illness that occurs in the Asia-Pacific region. Historically, strain characterization used serological analysis and revealed dramatic antigenic diversity. Eyeing a recommendation of potential vaccine candidates for broad protection, we review geographic diversity and serological and DNA prevalences. DNA analysis together with immunological analysis suggest that the prototype Karp strain and closely related strains are the most common throughout the region of endemicity. According to serological analysis, approximately 50% of isolates are seroreactive to Karp antisera, and approximately one-quarter of isolates are seroreactive to antisera against the prototype Gilliam strain. Molecular methods reveal greater diversity. By molecular methods, strains phylogenetically similar to Karp make up approximately 40% of all genotyped isolates, followed by the JG genotype group (Japan strains serotypically similar to the Gilliam strain but genetically non-Gilliam; 18% of all genotyped isolates). Three other genotype groups (Kato-related, Kawasaki-like, and TA763-like) each represent approximately 10% of genotyped isolates. Strains genetically similar to the Gilliam strain make up only 5% of isolates. Strains from these groups should be included in any potential vaccine.

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“…Evaluation of rickettsial virulence in mice has focused principally on rickettsial variants rather than on strain differences in the animal host. Isolates of R. tsutsugamushi evidence different virulence characteristics in laboratory mice (14,15), and some investigators have suggested a direct correlation between severity of human scrub typhus infections and virulence of the etiological strain for this laboratory host (3,6,13). Further extension of the concept suggested that rickettsial strains with reduced virulence for mice could be useful as attenuated strains for human immunization.…”

mentioning

confidence: 99%

Host Defenses in Experimental Scrub Typhus: Genetics of Natural Resistance to Infection

Groves

Osterman

1978

Infect Immun

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The Investigation of Fevers in North Queensland by Mouse Inoculation, With Particular Reference to Scrub Typhus

Cited by 23 publications

References 4 publications

SEROLOGICAL ANALYSIS OF RICKETTSIA TSUTSUGAMUSHI ISOLATES FROM NORTH QUEENSLAND*

SEROLOGICAL ANALYSIS OF RICKETTSIA TSUTSUGAMUSHI ISOLATES FROM NORTH QUEENSLAND*

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

Host Defenses in Experimental Scrub Typhus: Genetics of Natural Resistance to Infection

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