The investigation of cytotoxic and apoptotic activity of Cl-amidine on the human U-87 MG glioma cell line
Pinar Naile Öğüten,
Selin Engür Öztürk,
Miriş Dikmen
Abstract:Background:
Peptidyl (protein) arginine deiminases (PADs) provide the transformation of peptidyl arginine to peptidyl citrulline in the presence of calcium with posttranslational modification. The dysregulated PAD activity plays an important role on too many diseases including also the cancer. In this study, it has been aimed to determine the potential cytotoxic and apoptotic activity of chlorine-amidine (Cl-amidine) which is a PAD inhibitor and whose effectiveness has been shown in vitro and in vi… Show more
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