The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones

Abstract

New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehensive methods of analysis, including 1H NMR spectroscopy, GC-MS and elemental analysis.It has been found that compound 2a exhibits strong suppression of 5 test strains (MBC = 15.6 µg/mL). Compound 4a showed moderate inhibition of Salmonella pullorum, Escherichia coli O2, Salmonella enteritidis strains (MBC = 31.25 µg/mL) Compound 6a was sensitive toward ten tested bacteria at 31.25 µg/mL concentration.

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“…However, due to the increase in antimicrobial resistance every year, the effectiveness of treatment decreases. A new antimicrobial agent based on triazole was developed as an alternative to antibiotics (Karpun et al, 2021). However, the spectrum of action of the sensitivity of this tool was tested only on Salmonella pullorum, Salmonella typhimurium, Salmonella enteritidis, Escherichia coli O2.…”

Synthesis and Antibacterial Activity of Azomethine Ligand and Their Metal Complexes: A Combined Experimental and Theoretical Study

“…The research of Salahub et al [10] and Ellouz et al [11] analyzed DFT methods and their implementations to transition-metal reactions. Due to practical developments, this work has gained significant interest as a comprehensive review of the concepts of biologically active molecules [12].…”

Treatment of Subclinical Mastitis of Cows with Probiotics

“…These circumstances prompted researchers Ye. Karpun, V. Parchenko, T. Fotina, D. Demianenko, A. Fotin, V. Nahornyi, N. Nahorna (2021) to the search for new effective and at the same time low-toxic drugs that have innovative mechanisms of action. It was determined that triazole-3-thiols, which can be used as an alternative to antimicrobial agents, have bactericidal action against Staphylococcus aureus, Enterococcus faecalis, Salmonella pullorum, Salmonella typhimurium, Salmonella enteritidis, Escherichia vulgaris coli O 2 Clostridium perfringens (Karpun et al, 2021).…”