The Inverted Urothelial Papilloma

Abstract

3 additional cases of inverted urothelial papilloma are presented. A pathological, clinical and epidemiological review of this rare urothelial lesion is given.

Is Surveillance Necessary for Inverted Papilloma in the Urinary Bladder and Urethra?

“…Out of the 260 patients mentioned to have follow up 1−38 , inclusive of the present 20 patients, at least 10 patients (3.85%) were reported to have recurrence 3−11 . It was ‘at least’ because in one patient the exact site of the original inverted papilloma was not mentioned 5 .…”

“…Review of the English literature with respect to inverted papilloma known to be arising from the lower urinary tract produced 302 cases 1−62 , 282 cases in the bladder, 17 cases in the urethra and three cases in both 3 . Cheville et al.…”

Inverted Urothelial Papilloma: A Lesion with Malignant Potential

“…Furthermore, since the incidence of inverted urothelial papillomas is quite low, it is reasonable to think that dysplasia and definite malignancy of these tumors are not verted papilloma. Although suggestive, the endoscopic appearance of this lesion is not pathognomonic [4,5]: inverted papilloma is a polypoid pedunculated or sessile lesion, with a nonpapillary smooth to slightly lobulated surface [3,4,6]. The external surface should then represent the distinctive character though, according to several authors [7,8], it may also be papillary to some extent, which makes this lesion hard to distinguish from the commoner transitional cell papillary carcinoma [9].…”

Inverted Papilloma of the Renal Pelvis

“…The etiology of inverted papilloma is not yet clearly understood [18]. Several reports stress the importance of inflammatory causative factors because of the associa tion with cystitis glandularis and hyperplasia of Von Brunn's nests and for this reason inverted papilloma can also be called 'Brunnerioma'.…”