The inverse association between unhealthy eating habit and mucosal healing among patients with ulcerative colitis

Abstract

Background Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research has evaluated the association between eating habits and ulcerative colitis (UC). Thus, we investigate the association between eating behavior and clinical outcome in Japanese patients with UC. Methods Eating quickly, eating until full, and skipping breakfast data was obtained from a self-administered questionnaire. Information on clinical outcome was collected from medical records. Mucosal healing (MH) and partial MH was defined as a Mayo endoscopic subscore of 0 or 0–1, respectively. Age, sex, BMI, current smoking, current drinking, prednisolone use, and anti-TNFα monoclonal antibody use were selected a priori as potential confounding factors. Results Study subjects consisted of 294 Japanese patients with UC. Eating at speed moderate and eating quickly were independently inversely associated with MH: the adjusted odds ratios (ORs) were 0.38 (95% confidence interval [CI] 0.16–0.85) and 0.38 (95% CI 0.17–0.81) (p for trend = 0.033). Eating until full was independently inversely associated with MH: the adjusted OR was 0.38 (95% CI 0.27–0.86). MH in patients who skipped breakfast was marginally lower than that in patients who did not skip breakfast. No association between eating habits and clinical remission or partial MH was found. Conclusion Among patients with UC, eating rate and eating until full may be independently inversely associated with MH but not clinical remission.

The prevalence of allergic diseases is associated with clinical outcomes in ulcerative colitis

“…MH is associated with fewer early relapses [6,7], lowered rates of bowel resection [8] and colorectal cancer [9], and an improved quality of life [10,11]. Several factors, including unhealthy dietary habits [12], the severity of mucosal in ammation [13], duration of clinical remission [14], disease extent [14], and medication [13][14][15], affect the achievement of MH. However, the associated factors for MH remain unclear in UC patients.…”