The Invasive Species Reynoutria japonica Houtt. as a Promising Natural Agent for Cardiovascular and Digestive System Illness

Abstract

Polygoni Cuspidati Rhizoma et Radix, the dry roots and stems of Reynoutria japonica Houtt (called Huzhang, HZ in Chinese), is a traditional and popular chinese medicinal herb for thousands of years. As a widely used ethnomedicine in Asia including China, Japan, and Korea, HZ can invigorate the blood, cool heat, and resolve toxicity, which is commonly used in the treatment of favus, jaundice, scald, and constipation. However, HZ is now considered an invasive plant in the United States and many European countries. Therefore, in order to take advantage of HZ and solve the problem of biological invasion, scholars around the world have carried out abundant research studies on HZ. Until now, about 110 compounds have been isolated and identified from HZ, in which anthraquinones, stilbenes, and flavonoids would be the main bioactive ingredients for its pharmacological properties, such as microcirculation improvement, myocardial protective effects, endocrine regulation, anti-atherosclerotic activity, anti-oxidant activity, anti-tumor activity, anti-viral activity, and treatment of skin inflammation, burns, and scalds. HZ has a variety of active ingredients and broad pharmacological activities. It is widely used in health products, cosmetics, and even animal husbandry feed and has no obvious toxicity. Efforts should be made to develop more products such as effective drugs, health care products, cosmetics, and agricultural and animal husbandry products to benefit mankind.

Screening of CPT1A-Targeting Lipid Metabolism Modulators Using Mitochondrial Membrane Chromatography

“…It ameliorates metabolic disorders like obesity and dietary-induced hepatic steatosis . PCRR demonstrates a diverse range of pharmacological effects, including lipid regulation, anti-infection and anti-inflammatory properties, microcirculation improvement, myocardial protection, endocrine regulation, antiatherosclerosis, antioxidation, antitumor, and antiviral activities. , Given the presence of lipid-metabolism-modulating components in SR and PCRR, there is significant promise for the screening of lipid metabolism-regulating effector molecules targeting CPT1A.…”

“…9 PCRR demonstrates a diverse range of pharmacological effects, including lipid regulation, anti-infection and anti-inflammatory properties, microcirculation improvement, myocardial protection, endocrine regulation, antiatherosclerosis, antioxidation, antitumor, and antiviral activities. 19,20 Given the presence of lipidmetabolism-modulating components in SR and PCRR, there is significant promise for the screening of lipid metabolismregulating effector molecules targeting CPT1A. The two-dimensional CPT1A/MMC−LC/MS system was applied to analyze the crude extracts of SR and PCRR, and the results are presented in Figure 6.…”

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

“…The extract of Polygoni Cuspidati Rhizoma et Radix exhibits anti-inflammatory activities via inhibiting NF- κ B and downregulating tumor necrosis factor- α (TNF- α ) and interleukin-6 (IL-6) 296 . The main components of Polygoni Cuspidati Rhizoma et Radix include quinones, stilbenes, and flavonoids 297 . Resveratrol, a primary component of Polygoni Cuspidati Rhizoma et Radix, was primarily metabolized by UGT1A1, UGT1A9, and gut microbiota 298 , 299 .…”