The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states
Milena Doroszko,
Rebecka Stockgard,
Irem Yildirim
et al.
Abstract:Glioblastoma (GBM), the most common brain cancer in adults, is characterized by rapid local invasion, along diverse routes such as infiltration of white matter tracts and penetration of perivascular spaces. We investigate the hypothesis that GBM invasion routes correlate with the transcriptional states of individual cells and identify route-specific master regulator genes. Utilizing patient-derived GBM xenograft models, we integrate single-cell transcriptomics and spatial proteomics, revealing that mesenchymal… Show more
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