The Intriguing Conundrum of a Nonconserved Multifunctional Protein of Citrus Tristeza Virus That Interacts with a Viral Long Non-Coding RNA

Kang, Seong-Gil; Aknadibossian, Vicken; Kharel, Laxmi; Mudiyanselage, Shachinthaka D. Dissanayaka; Wang, Ying; Folimonova, Svetlana Y.

doi:10.3390/v13112129

Cited by 4 publications

(3 citation statements)

References 65 publications

(117 reference statements)

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“…LncRNA ASP of HIV can recruit PRC2 to the 5' LTR of HIV-1 to suppress the H3K27 trimethylation and establish the latency of HIV-1 [46,80]. The binding of CTV LMT1 with CTV p33 may help CTV to persist in the host for the whole tree life, and when arrive at sufficient titers to be transmitted to a new host [49].…”

Section: Viral Lncrnas Contribute To Viral Persistent Infectionsmentioning

confidence: 99%

“…RNase L ciRNA produced by Group C enteroviruses (GCE) inhibits the function of the ISG RNase L [85]. CTV LMT1 was reported to play a role in modulating plant antiviral response by limiting the production of reactive oxygen species (ROS) [49]. VA RNA prevents the phosphorylation of eIF2 (translation initiation factor 2) through inhibiting the host PKR signaling and resists the antiviral response of the host cell [86].…”

Section: Viral Lncrnas Contribute To Resistance To Antiviral Immune R...mentioning

confidence: 99%

“…Another example is LMT1 (low-molecular-weight tristeza 1), a 5'-terminal long non-coding RNA which was produced by CTV (Citrus tristeza virus). LMT1 can bind CTV p33 protein and contribute to the viral persistence in the host for the whole tree life [49].…”

Section: Introductionmentioning

confidence: 99%

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Viral long non-coding RNA regulates virus life-cycle and pathogenicity

Gao

Xiang

et al. 2022

Mol Biol Rep

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High throughput analyses reveal that the majority of the genome is transcribed into RNAs, but less than 2% of them are translated into proteins [2][3][4][5][6]. Therefore, most transcripts are non-coding RNAs (ncRNAs) [4][5][6]. In recent years, a large number of ncRNAs have been found to have regulatory functions in various physiological and pathological processes. According to their length, regulatory ncRNAs are classified into short non-coding RNAs (< 200 nt) and long non-coding RNAs (lncRNAs, > 200 nt). Short noncoding RNAs include microRNAs (miRNAs), small interfering RNAs (siRNAs), and piwiRNAs (piRNAs) [4,6,7]. LncRNAs are the products of RNA polymerase II or III, and are often 5 '-capped, 3'-polyadenylated and spliced[3, 8, 9]. Based on the locations in the genome, lncRNAs are divided into antisense, sense, bidirectional, intergenic, and intronic ones [9]. Compared with mRNA, the expression of lncRNA is much lower and shows cell-and tissue-specificity [10,11]. Recently, lncRNAs have been identified as critical regulators in several biological processes including gene expression, chromatin modification, cell apoptosis, cell Xiumei Sheng

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Section: Viral Lncrnas Contribute To Viral Persistent Infectionsmentioning

confidence: 99%

Section: Viral Lncrnas Contribute To Resistance To Antiviral Immune R...mentioning

confidence: 99%

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Viral long non-coding RNA regulates virus life-cycle and pathogenicity

Gao

Xiang

et al. 2022

Mol Biol Rep

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Long Noncoding RNAs in Plant–Pathogen Interactions

Wang

Folimonova

2023

Phytopathology®

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Long noncoding RNAs (lncRNAs) are commonly defined as transcripts that lack protein-coding capacity and are longer than 200 nucleotides. Since the emergence of next-generation sequencing technologies in this century, thousands of lncRNAs have been identified from nearly all living organisms. Notably, various pathogens also express their own lncRNAs in host cells during infection. In plants, many lncRNAs exhibit dynamic expression patterns in response to environmental stimuli, including pathogen attacks. In contrast to well-established methods in identifying such lncRNAs, the current understanding of lncRNAs’ functional mechanisms is in its infancy. Some lncRNAs serve as precursors for generating small RNAs or serve as target mimics to sequester functional small RNAs, which have been extensively reviewed in the literature. This review focuses on the emerging evidence supporting that certain lncRNAs function as negative or positive regulators of plant immunity. A common theme is that those regulations rely on specific interactions between lncRNAs and key regulatory proteins. Viroids as single-stranded circular noncoding RNAs provide a handle to investigate how RNA local motifs render interaction specificity between lncRNAs and regulatory proteins.

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Citrus Tristeza Virus: From Pathogen to Panacea

Folimonova

Sun

2022

Annu. Rev. Virol.

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Citrus tristeza virus (CTV) is the most destructive viral pathogen of citrus. During the past century, CTV induced grave epidemics in citrus-growing areas worldwide that have resulted in a loss of more than 100 million trees. At present, the virus continues to threaten citrus production in many different countries. Research on CTV is accompanied by distinctive challenges stemming from the large size of its RNA genome, the narrow host range limited to slow-growing Citrus species and relatives, and the complexity of CTV populations. Despite these hurdles, remarkable progress has been made in understanding the CTV-host interactions and in converting the virus into a tool for crop protection and improvement. This review focuses on recent advances that have shed light on the mechanisms underlying CTV infection. Understanding these mechanisms is pivotal for the development of means to control CTV diseases and, ultimately, turn this virus into an ally. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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The Intriguing Conundrum of a Nonconserved Multifunctional Protein of Citrus Tristeza Virus That Interacts with a Viral Long Non-Coding RNA

Cited by 4 publications

References 65 publications

Viral long non-coding RNA regulates virus life-cycle and pathogenicity

Viral long non-coding RNA regulates virus life-cycle and pathogenicity

Long Noncoding RNAs in Plant–Pathogen Interactions

Citrus Tristeza Virus: From Pathogen to Panacea

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