The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

Liu, Ning-Ning; Yi, Cheng-Xiang; Wei, Lu-Qi; Zhou, Jin-An; Jiang, Tong; Hu, Cong-Cong; Wang, Lu; Wang, Yuan-Yuan; Zou, Yun; Zhao, Yi-Kai; Zhang, Le-Le; Nie, Ya-Ting; Zhu, Yi-Jing; Yi, Xin-Yao; Zeng, Ling-Bing; Li, Jing-Quan; Huang, Xiao-Tian; Ji, Hong-Bin; Kozlakidis, Zisis; Zhong, Lin; Heeschen, Christopher; Zheng, Xiao-Qi; Chen, Changbin; Zhang, Peng; Wang, Hui

doi:10.1016/j.ccell.2023.08.012

Cited by 37 publications

(17 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…95 And in terms of fungi, we have investigated that Aspergillus sydowii-infected lung cancer mice models treated with amphotericin B, a polyene antifungal, have blocked the tumour progression by destroying the activation of MDSCs by reducing IL-1β secretion via β-glucan/Dectin-1/CARD9 pathway. 20 Similarly, other studies have found that the gastrointestinal microbiota-AMPK-mTOR axis can affect the progression of HCC, suggesting that the influence of tissue microbiota on the body may not be limited to the site of microbial settlement. 96 The identification of several genes involved in skin cancer suggests that resident microbiota may play a role in skin cancer susceptibility and its potential prevention and/or treatment.…”

Section: Microbiota As Emerging Targets For Anticancer Therapymentioning

confidence: 92%

“…16,17 Other studies have also linked the development of lung cancer to specific microorganisms and dysregulated microbiomes. [18][19][20][21] The direct correlation between oral microbiota imbalance and the incidence of oral squamous cell carcinoma (OSCC) has been demonstrated. 22,23 In the clinical management of individuals with metastatic CRC and non-small cell lung cancer (NSCLC; cetuximab+avelumab, two drugs), it has been shown that gut microbiota (Agathobacter, Blautia) appears to be potential biomarkers in predicting the outcome of NSCLC patients.…”

Section: Microbes Serve As Prognostic Biomarker Associated With Cance...mentioning

confidence: 99%

See 1 more Smart Citation

Host–microbiota interaction during cancer progression from bulk to single‐cell level

Ma,

Zhu,

Liu

2024

Clinical and Translational Dis

Self Cite

View full text Add to dashboard Cite

BackgroundCancer, a global threat to human health, refers to a large crowd of lethal diseases that can start in almost all tissues or organs of our body when abnormal cells grow uncontrollably and beyond their usual boundaries, followed by invading adjacent normal tissues and spreading to distant organs. Recently, substantial evidence has demonstrated polymorphic microbiome as an emerging cancer characteristic present in a variety of tumour types. By releasing metabolites or other signalling molecules, microbiota can affect immune cell differentiation and activity, including both innate and adaptive immunological responses, as well as the growth and multiplication of cancer cells. It was now employed as a biomarker to predict the patients’ survival rate and the degree of cancer progression.MainTo investigate the underlying mechanism and the technology development of how polymorphic microbiome influence the tumour microenvironment and subsequently cancer progression, we have carried out systematic literature review about polymorphic microbiome and tumour development from bulk to single‐cell level.ConclusionsHere, we provide an overview of the current advancements of host–microbiota interactions during cancer progression from bulk to single‐cell level and discuss the challenges and opportunities in future, looking forward to ascertain the specific activity of different somatic cell types with or without the existence of various multi‐kingdom microbiota and their by‐products and supply a holistic and elaborate investigation of host‐microbiota interaction in the development of cancer.

show abstract

Section: Microbiota As Emerging Targets For Anticancer Therapymentioning

confidence: 92%

Section: Microbes Serve As Prognostic Biomarker Associated With Cance...mentioning

confidence: 99%

Host–microbiota interaction during cancer progression from bulk to single‐cell level

Ma,

Zhu,

Liu

2024

Clinical and Translational Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, another study demonstrated for the first time that a variety of unique “intracellular bacteria” present in breast cancer tissues play a key role in tumor metastasis and colonization, which is also a major breakthrough in the traditional theory of tumor metastasis [354]. In addition to bacteria, another group of microbial fungi are also prevalent in different tumors, and they are closely associated with tumor metastasis and reduced survival of cancer patients [355]. Although the gut microbiota has been at the forefront of research, a number of recent studies have shown that a variety of tumors coexist with the microbiota, and with studies confirming the prevalence of fungi, similar to the gut flora, in tumor tissues of 35 different cancer types, there is also a growing recognition that the polymorphic microbiome, as a hallmark of cancer, has a profound impact on tumor progression and response to anticancer therapies [354, 356].…”

Section: Cell‐autonomous and Non‐autonomous Emerging Functions Of P53...mentioning

confidence: 99%

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

Song,

Yang,

Zhang

2024

Cancer Communications

View full text Add to dashboard Cite

Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding p53, regulates numerous downstream genes and cellular phenotypes in response to various stressors. The affected genes are involved in diverse processes, including cell cycle arrest, DNA repair, cellular senescence, metabolic homeostasis, apoptosis, and autophagy. However, accumulating recent studies have continued to reveal novel and unexpected functions of p53 in governing the fate of tumors, for example, functions in ferroptosis, immunity, the tumor microenvironment and microbiome metabolism. Among the possibilities, the evolutionary plasticity of p53 is the most controversial, partially due to the dizzying array of biological functions that have been attributed to different regulatory mechanisms of p53 signaling. Nearly 40 years after its discovery, this key tumor suppressor remains somewhat enigmatic. The intricate and diverse functions of p53 in regulating cell fate during cancer treatment are only the tip of the iceberg with respect to its equally complicated structural biology, which has been painstakingly revealed. Additionally, TP53 mutation is one of the most significant genetic alterations in cancer, contributing to rapid cancer cell growth and tumor progression. Here, we summarized recent advances that implicate altered p53 in modulating the response to various cancer therapies, including chemotherapy, radiotherapy, and immunotherapy. Furthermore, we also discussed potential strategies for targeting p53 as a therapeutic option for cancer.

show abstract

“…Clinical research also confirms that inhibiting IL-1β significantly reduces the incidence rate of lung cancer in a dose-dependent manner ( 48 ). Lung cancer cells secrete IL-6 and IL-11, which can activate various signaling pathways such as PI3K/Akt and MAPK, promoting cell proliferation and migration ( 49 – 52 ). In vitro studies reveal that IL-11 can stimulate OC formation and activation, accelerate bone resorption, and release growth factors such as TGF-β in the bone matrix, thereby promoting the growth and metastasis of lung cancer cells ( 53 ).…”

Section: The Role Of the Bone Marrow Microenvironment In Lung Cancer ...mentioning

confidence: 99%

Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment

Li,

Wu,

Xie

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Bone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival environment for metastasizing tumor cells (“seeds”). The bone marrow microenvironment, comprising a complex array of cells, includes bone marrow adipocytes (BMAs), which constitute about 70% of the adult bone marrow volume and may play a significant role in tumor bone metastasis. BMAs can directly provide energy for tumor cells, promoting their proliferation and migration. Furthermore, BMAs participate in the tumor microenvironment’s osteogenesis regulation, osteoclast(OC) regulation, and immune response through the secretion of adipokines, cytokines, and inflammatory factors. However, the precise mechanisms of BMAs in lung cancer bone metastasis remain largely unclear. This review primarily explores the role of BMAs and their secreted adipokines (leptin, adiponectin, Nesfatin-1, Resistin, chemerin, visfatin) in lung cancer bone metastasis, aiming to provide new insights into the mechanisms and clinical treatment of lung cancer bone metastasis.

show abstract

The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

Cited by 37 publications

References 114 publications

Host–microbiota interaction during cancer progression from bulk to single‐cell level

Host–microbiota interaction during cancer progression from bulk to single‐cell level

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment

Contact Info

Product

Resources

About