The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord

Ebersberger, Andrea; Grubb, Blair D.; Willingale, H.L; Gardiner, Natalie J.; Nebe, J.; Schaible, H.-G.

doi:10.1016/s0306-4522(99)00164-5

Cited by 115 publications

(76 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a rat model of acute arthritis Ebersberger et al demonstrated enhanced release of intraspinal prostaglandin E 2 after seven to eight hours, with maximum elevation of cyclo-oxygenase-2 protein levels 12 hr after the induction of inflammation. 15 These findings are in keeping with reduced central sensitization.…”

Section: (D1) Group 3 (D2) (N = 30) (N = 30) (N = 30) Vas (Rest) Vas supporting

confidence: 76%

“…14,15 Corticosteroids are known to inhibit phospholipase A2 and expression of cyclo-oxygenase-2 during inflammation, thus reducing prostaglandin synthesis. 16 Intrathecal injection of corticosteroids in the rat model has been shown to have no effect on acute high intensity stimuli, despite a mild effect on nociceptor driven spinal sensitization.…”

Section: B Enefits Of Laparoscopic Cholecystectomymentioning

confidence: 99%

See 1 more Smart Citation

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Thomas

Beevi

2006

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose: Epidural steroids may have potential advantages for providing postoperative analgesia. We therefore undertook a study to evaluate the efficacy of epidurally administered dexamethasone in reducing postoperative morphine requirements, as a measure of analgesia following laparoscopic cholecystectomy. Methods:In a randomized, double-blind study, 94 patients undergoing laparoscopic cholecystectomy were randomly assigned to one of three groups. Group 1 (Control) patients received dexamethasone 5 mg iv with epidural injection of 0.25% bupivacaine 8 mL and normal saline 2 mL, Group 2 (D1) patients received normal saline 2 mL iv with epidural injection of 0.25% bupivacaine 8 mL and dexamethasone 5 mg in normal saline 2 mL, and Group 3 (D2) patients received normal saline 2 mL iv with epidural injection of dexamethasone 5 mg in normal saline 10 mL. After surgery, morphine 2-4 mg iv was administered as needed for analgesia. Postoperative morphine requirements, visual analogue scale (VAS) pain scores at rest and with effort, and time to first analgesic administration were recorded by a blinded observer. Results:Total morphine consumption for the first 24 hr following surgery was lower in both epidural dexamethasone groups (D1, D2) compared to the control group (P < 0.05). The percentage reduction in morphine consumption in Group D1 was 53.9% and in Group D2 was 52.9% in the first 24 hr. Postoperatively at 12 hr, 18 hr and 24 hr, the VAS scores at rest and during effort were also lower in the epidural dexamethasone groups (D1, D2) compared to the control group (P < 0.05). The percentage reductions in VAS scores with effort at 12 hr, 18 hr and 24 hr in Group D1 were 50%, 52.9% and 50% respectively, and in Group D2 percentage reductions in pain scores with effort were 54.8%, 58.8% and 55.5% at corresponding sampling intervals. Conclusion:Preoperative epidural administration of dexamethasone 5 mg, with or without bupivacaine, reduces postoperative pain and morphine consumption following laparoscopic cholecystectomy. Objectif

show abstract

Section: (D1) Group 3 (D2) (N = 30) (N = 30) (N = 30) Vas (Rest) Vas supporting

confidence: 76%

Section: B Enefits Of Laparoscopic Cholecystectomymentioning

confidence: 99%

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Thomas

Beevi

2006

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…These activate the N-methyl-D-aspartate receptors of the dorsal horn neurons in the spinal cord, with a consequent increase in the intracellular calcium ion which is needed for activation of the enzyme phospholipase A2, which mobilizes arachidonic acid. Almost immediately, the expression of cyclo-oxygenase 2 is up-regulated, triggering the release of prostaglandin E2, which results in a hyperalgesic state 15 .…”

Section: ■ Discussionmentioning

confidence: 99%

“…Animals in the other three treatment groups were given epidural injection of 2% lignocaine (2.0 mg/kg, mean dose 1.1 mL) containing either 2 mg dexamethasone phosphate (Treatment LIDEX2, mean dose 0.8 mL; Decadron 4 mg/mL, Aché Laboratórios Farmacêuticos S.A., Guarulhos, BR), 4 mg dexamethasone phosphate (Treatment LIDEX4, mean dose 1.4 mL) or 8 mg dexamethasone phosphate (Treatment LIDEX8, mean dose 1.6 mL). The dexamethasone doses used in this experiment were based on previous studies in humans 2,14,15 . All physiological data were monitored: heart rate (HR); respiratory rate (RR); systolic (SAP), diastolic (DAP), and mean (MAP) arterial blood pressures; and rectal temperature (RT) at baseline (T 0 ), 10 minutes after premedication (T 10 ), after the start of TIVA (T 20 ), after epidural injections (T 30 ), 60 min after epidural injections (T 60 ), and 120 min after epidural injections (T 120 ).…”

Section: Experimental Designmentioning

confidence: 99%

“…The exact mechanism of this analgesic effect is not understood 12 , but several mechanisms have been suggested to explain it 13,14 . Inhibition of phospholipase A2 and cyclooxygenase-2 expression by steroids during inflammation reduces prostaglandin synthesis and subsequently decreases the hyperalgesia associated with acute nociception during surgery 15 .…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of epidurally administered dexamethasone with lignocaine for post-operative analgesia in dogs undergoing ovariohysterectomy. A dose-response study

Hermeto

Rossi²,

Bicudo³

et al. 2017

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose: To evaluate the postoperative analgesic and adverse effects of three doses of dexamethasone, administered epidurally in combination with lignocaine, in dogs undergoing ovariohysterectomy (OVH). Methods: Twenty-four female dogs undergoing ovariohysterectomy were pre-medicated with acepromazine and general anaesthesia was induced and maintained with propofol. Animals were randomly allocated into four groups of six. The control group was given lignocaine 2% (LI) and the treatment groups were given lignocaine with either 2 mg dexamethasone (LIDEX2), 4 mg dexamethasone (LIDEX4) or 8 mg dexamethasone (LIDEX8) administered at the lumbosacral epidural space. Duration of postoperative analgesia, first analgesic rescue, motor blockade, heart rate, blood pressure, respiratory rate, and rectal temperature were evaluated. Results: The duration of postoperative analgesia was 19.5 (SD 6) hours for LIDEX8 (p=0.001), 10 (SD 2) hours for LIDEX4 (p=0.002), 4 (SD 2) hours for LIDEX2 (p=0.074) treatments compared with values for the LI control treatment 2.2 (SD 1.6) hours. All treatments had significant cardiovascular and respiratory alterations but they were within acceptable range in these clinically healthy female dogs. Conclusion: Dexamethasone added to epidural lignocaine significantly extends the postoperative analgesia after ovariohysterectomy in female dogs.

show abstract

Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis

Drachman

Rothstein²

2000

Ann Neurol.

112

View full text Add to dashboard Cite

The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord

Cited by 115 publications

References 34 publications

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

The effect of epidurally administered dexamethasone with lignocaine for post-operative analgesia in dogs undergoing ovariohysterectomy. A dose-response study

Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis

Contact Info

Product

Resources

About