The Intrarenal Venous Pressure

Swann, H. G.; Hink, B. W.; Koester, H; Moore, Victor S.; Prine, J. M.

doi:10.1126/science.115.2977.64

Cited by 26 publications

(7 citation statements)

References 4 publications

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“…These observations appear to be in contrast to previous studies that have demonstrated increases in intrarenal venous pressure during solute diuresis (6)(7)(8). However, osmotic diuresis results in increased renal blood flow (11) and reduced renal vascular resistance, and this may account in part for increased intrarenal pressure during mannitol, glucose or urea diuresis (6)(7)(8).…”

contrasting

confidence: 78%

“…Although the deep renal venous pressure must be less than true capillary pressure, it appears that changes in intrarenal venous pressure parallel changes in capillary pressure and are at least equal to the surrounding tissue pressure (6)(7)(8)(9)(10). It is therefore reasonable to conclude that changes in deep intrarenal pressure qualitatively reflect changes in capillary hydrostatic pressure.…”

Section: Discussionmentioning

confidence: 99%

“…Studies by others have demonstrated that deep (wedged) intrarenal venous pressure may closely approximate peritubular capillary pressure in the rat (6) and that this pressure is increased during such procedures as osmotic diuresis (6)(7)(8). Although the deep renal venous pressure must be less than true capillary pressure, it appears that changes in intrarenal venous pressure parallel changes in capillary pressure and are at least equal to the surrounding tissue pressure (6)(7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Intrarenal Hydrostatic Pressure and Hemodynamically Induced Changes in Sodium Excretion

Martino

Earley

1968

Circulation Research

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Deep intrarenal venous pressure was used as an index of renal capillary pressure to test the proposal that physically induced changes in sodium reabsorption may be mediated by changes in Starling forces across the capillary. Renal vasodilatation produced natriuresis associated with immediate increases in intrarenal venous pressure. Increased arterial pressure was accompanied by further natriuresis and initially increased intrarenal pressure in vasodilated kidneys. Plasma load was always accompanied by increased intrarenal venous pressure. Saline loading usually increased intrarenal venous pressure, and restoration of plasma protein concentration during saline loading reduced, but did not abolish, natriuresis. This continued natriuresis was associated with reduced renal vascular resistance and increased intrarenal venous pressure, demonstrating that continued natriuresis after restoring plasma oncotic pressure during saline loading could relate to increased capillary hydrostatic pressure. Intrarenal venous pressure did not relate to isolated changes in urine flow, arterial pressure, or renal blood flow. These observations support the hypothesis that changes in peritubular capillary hydrostatic pressure initiate changes in tubular sodium reabsorption as a result of changes in capillary uptake.

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contrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship between Intrarenal Hydrostatic Pressure and Hemodynamically Induced Changes in Sodium Excretion

Martino

Earley

1968

Circulation Research

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“…13). In the mature kidney, this pressure drop may be localized to the junction of arcuate and interlobar veins (36), an area in which venous valves have been demonstrated (37). If these valves influence renal venous resistance, then their growth during the postnatal period may have contributed to the rise in peritubular capillary pressure.…”

Section: Resultsmentioning

confidence: 99%

Postnatal development of renal function: micropuncture and clearance studies in the dog

Horster¹,

Valtin²

1971

J. Clin. Invest.

191

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A B S T R A C T Postnatal renal development was studied in dogs between 2 and 77 days. Single, superficial nephrons were evaluated by micropuncture, concurrently with measurements of total renal function and morphometric analyses in the same animals.Glomerular filtration rate for the entire kidney increased linearly from 0.13 ml/min per g kidney weight at 2 days to 0.91 at 77 days. Extraction of p-aminohippurate increased from about 20 to 80%, and renal plasma flow per g kidney weight, measured as CPAH/EPAH, increased threefold during the same period. Filtration fraction increased to the mature value during the first half of the postnatal period studied.The clearance of urea per unit of renal mass increased with age, whereas the fraction of filtered urea reabsorbed declined during the early part of the postnatal period. The pattern of fractional urea reabsorption may be due mainly to increased medullary recycling of urea and to a rise in the reabsorption of water from the medullary collecting duct.Urine osmolality was higher than plasma from birth onward and rose with age. Osmolal equality of collecting duct fluid and medullary interstitium reflected mature vasopressin (ADH)-induced water permeability. The rise in urinary concentration was predominantly due to increasing medullary sequestration of urea.Glomerular filtration rate of the superficial nephron A preliminary report on part of this work appeared in abstract form: Horster, M. 1970. Postnatal fluid reabsorption in single nephrons of the dog kidney. J. Clin. Invest.

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“…In the dog, wedged renal vein pressure measurements are comparable to values obtained by direct needle measurements of intrarenal pressure (Swann et al, 1952b). Brun et aZ(l956) and Stahl (1966) demonstrated the feasibility of measuring wedged renal vein pressure (WRVP) in man and proposed that it might provide an estimate of renal interstitial pressure.…”

mentioning

confidence: 86%

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

et al. 1970

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1. Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension. Despite increased afferent arteriolar resistance, glomerular pressure was elevated indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal pressure.2. During hypertonic saline loading in hypertensives, renal arteriolar resistance falls, resulting in further increase in intrarenal pressure. Increments in intrarenal pressure paralleled increases in sodium excretion in patients with essential hypertension during the exaggerated natriuresis and in normotensive subjects after the prolonged infusion of hypertonic saline.3. The marked increase in intrarenal pressure which appears to be responsible for exaggerated natriuresis in essential hypertension is attributable to an altered (exaggerated) response of the renal arterioles. The data suggest that elevated intrarenal pressure may play a role in the regulation of sodium balance in patients with essential hypertension.While many investigators have noted that patients with essential hypertension excrete more sodium than normotensive subjects in response to the infusion of hypertonic saline, the mechanism for this exaggerated natriuresis is not known (Baldwin et al.

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The Intrarenal Venous Pressure

Cited by 26 publications

References 4 publications

Relationship between Intrarenal Hydrostatic Pressure and Hemodynamically Induced Changes in Sodium Excretion

Relationship between Intrarenal Hydrostatic Pressure and Hemodynamically Induced Changes in Sodium Excretion

Postnatal development of renal function: micropuncture and clearance studies in the dog

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

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