The Intraoperative Corneal Pachymetry Changes during Accelerated Corneal Cross-linking in Progressive Keratoconus Patients with Thin Corneas

Ocak, Serap Yurttaşer; Mangan, Mehmet Serhat; Elçioğlu, Mustafa Nuri

doi:10.3341/kjo.2021.0111

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…Hong CW et al ( 5 ) reported that collagenase treatment resulted in a significant increase in corneal curvature in human corneas by 6.6 ± 1.1 D. Wang X et al ( 7 ) demonstrated that rabbit corneas exposed to collagenase ex vivo showed a significant decrease in CCT. Regarding corneal thickness during accelerated CXL in clinical KC, Ocak et al ( 10 ) found a significant decrease at the end of ultraviolet-A irradiation. They also reported a significant decrease in endothelial cell density postoperatively ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…Corneal epithelial peeling in CXL not only induces ocular pain after surgery but also carries a potential risk of corneal infection. Some modified CXL-associated accelerated and/or transepithelial techniques have recently become popular in the treatment of KC ( 10 , 11 ). KeraVio treatment avoids these complications of CXL surgery and may become another option for KC treatment, but its efficacy has not been compared with that of CXL.…”

Section: Introductionmentioning

confidence: 99%

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Combination of violet light irradiation and collagenase treatments in a rabbit model of keratoconus

Kobashi

Yano²,

Tsubota

2023

Front. Med.

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PurposeWe evaluated the use of collagenase treatment to generate a rabbit model of keratoconus and the impact of violet light (VL) irradiation on the disease model in six Japanese White rabbits.MethodsAfter epithelial debridement, the collagenase group was treated with a collagenase type II solution for 30 min; the control group was treated with a solution without collagenase. Three rabbits also underwent VL irradiation (375 nm, irradiance 310 μW/cm2) for 3 h daily for 7 days after topical collagenase application. Slit-lamp microscopy results, steep keratometry (Ks), corneal astigmatism, central corneal thickness, and axial length were examined before and after the procedure. The corneas were obtained on day 7 for biomechanical evaluation.ResultsA significant increase in Ks and corneal astigmatism was observed in the collagenase and VL irradiation groups compared with the control group on day 7. No significant difference was found in the change in corneal thickness between the groups. The elastic modulus at 3, 5, and 10% strain was significantly lower in the collagenase group than in the control group. There was no significant difference in the elastic modulus at any level of strain between the collagenase and VL irradiation groups. The average axial length at day 7 was significantly longer in the collagenase and VL irradiation groups than in the control group. Collagenase treatment induced a model of keratoconus by steepening the keratometric and astigmatic values. There was no significant difference in the observed elastic behavior of normal and ectatic corneas under physiologically relevant stress levels.ConclusionVL irradiation did not cause regression of corneal steepening in a collagenase-induced model during short-term observation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination of violet light irradiation and collagenase treatments in a rabbit model of keratoconus

Kobashi

Yano²,

Tsubota

2023

Front. Med.

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“…The corneal saturation step acts as a photosensitizer to promote crosslinking, while the UVA irradiation stage protects the underlying tissues from UVA-induced damage. 21 Conventional CXL will result in cross-linking through two pathways, namely oxidative and glycosylation pathways. 22 Activated riboflavin, in addition to activating oxidative pathways, can also support the occurrence of glycosylated cross-linking in proteoglycans and collagen fibers through a mechanism mediated by advanced glycation end products.…”

Section: Cct After CXLmentioning

confidence: 99%

Safety of transglutaminase-induced corneal collagen cross-linking on the central cornea thickness and intraocular pressure in vivo

Sitorasmi

Ningtiyas²,

Wahyuni³

et al. 2023

F1000Res

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Background: Corneal collagen cross-linking (CXL) is a procedure for making bonds that connect polymer chains to one another. Corneal CXL aims to slow or stop the progression of keratoconus by using photooxidative therapy so as to increase stromal rigidity. Transglutaminase enzymes are currently widely used in the food industry. Recent studies have shown that mRNA, fibronectin, and transglutaminase were found to be more abundant in human corneal keratocytes treated with UVA and riboflavin. Transglutaminase is considered to reduce discomfort caused by UVA irradiation. Methods: A total of 21 white New Zealand rabbits were divided into three groups, namely, transglutaminase-induced CXL group, epithelial-off CXL group, and transepithelial CXL group. The ocular surface was treated with a 1 U/mL microbial transglutaminase solution, and both the epithelial-off and transepithelial groups were exposed to clinical ultraviolet A-riboflavin (UVA/RF). The efficacy of each group was evaluated on the 14th day after the procedures. The central corneal thickness (CCT) and intraocular pressure (IOP) were evaluated using Corneal Visualization Scheimpflug Technology (Corvis ST). Results: The transglutaminase-induced CXL group exhibited the highest mean CCT (370.14 ± 38.85) in comparison with the UVA/RF epithelial-off group (368.00 ± 25.48) and the UVA/RF transepithelial group (369.86 ± 23.43). The transglutaminase-induced CXL group had the highest IOP mean (8.50 ± 3.02) compared with the UVA/RF epithelial-off (6.50 ± 3.07) and UVA/RF transepithelial groups (7.00 ± 1.90). There were no significant differences in CCT (p = 0.990) or IOP (p = 0.563) between the groups. Conclusions: The findings of this study suggest that there are no significant differences between the transglutaminase-induced CXL group and the UVA/RF CXL group. The safety of transglutaminase-induced CXL could be comparable to that of UVA/RF CXL in terms of altering CCT and IOP, which are two factors contributing to corneal rigidity.

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The Intraoperative Corneal Pachymetry Changes during Accelerated Corneal Cross-linking in Progressive Keratoconus Patients with Thin Corneas

Abstract: The intra-operative corneal pachymetry changes during accelerated corneal cross-linking in progressive keratoconus patients with thin corneas

Cited by 2 publications

References 26 publications

Combination of violet light irradiation and collagenase treatments in a rabbit model of keratoconus

Combination of violet light irradiation and collagenase treatments in a rabbit model of keratoconus

Safety of transglutaminase-induced corneal collagen cross-linking on the central cornea thickness and intraocular pressure in vivo

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