The intraocular pressure response to dehydration: a pilot study

Hunt, Andrew P.; Feigl, Beatrix; Stewart, Ian B.

doi:10.1007/s00421-011-2143-5

Cited by 17 publications

(20 citation statements)

References 10 publications

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“…decreases in hydration status) took place during higher temperatures and with prolonged exercise because the hypotonic fluid losses via sweating were greater. While this was a small pilot study, a moderate correlation between decline in IOP and decline in hydration status (adjusted r 2 = 0.51) was found, suggesting IOP progressively decreases with progressive dehydration . However, an older study is noteworthy in which participants were subjected to graded exercise to exhaustion (with and without additional CO 2 inhalation for isocapnia) over 19–22 min (excluding two periods of 2 min rest) and fixed intensity exercise for 10 min, all on separate occasions.…”

Section: Search Strategymentioning

confidence: 88%

“…While this was a small pilot study, a moderate correlation between decline in IOP and decline in hydration status (adjusted r 2 = 0.51) was found, suggesting IOP progressively decreases with progressive dehydration. 47 However, an older study 59 is noteworthy in which participants were subjected to graded exercise to exhaustion (with and without additional CO2 inhalation for isocapnia) over 19-22 min (excluding two periods of 2 min rest) and fixed intensity exercise for 10 min, all on separate occasions. The IOP declined relative to sedentary controls during the trial, but because the plasma osmolarity was equal to, or slightly lower than baseline after exercise, no correlation between IOP and plasma osmolarity was found, indicating the hydration status of the participants did not change during the trial.…”

Section: -55mentioning

confidence: 99%

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Hydration, fluid regulation and the eye: in health and disease

Sherwin

Kokavec

Thornton

2015

Clinical Exper Ophthalmology

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Variation in systemic hydration status, namely chronic systemic hypohydration or dehydration, can influence the development of several chronic non-ophthalmic diseases. Owing to the eye's high water content and unique system of fluid regulation, we hypothesized that hydration status may affect the eye in health and disease states. Therefore, we performed a systematic review of the current evidence implicating changes in hydration and their association with ocular physiology and morphological characteristics. We also reviewed relevant clinical correlations of changes in hydration and major common eye diseases. Our findings suggest that systemic hydration status broadly affects a variety of ocular pathophysiologic processes and disease states. For example, dehydration may be associated with development of dry eye syndrome, cataract, refractive changes and retinal vascular disease. On the other hand, excessive hydration is associated with some ocular diseases. Tear fluid osmolarity may be an effective marker of systemic hydration status. Recent studies implicate chronic renin-angiotensin-aldosterone system activation in the pathogenesis of diabetic retinopathy and glaucoma but also suggest its antagonism may be a useful therapeutic target. Our findings indicate that assessment of hydration status may be an important consideration in the management of patients with chronic eye diseases and undergoing eye surgery. Further research investigating the role of acute and chronic changes in hydration in individuals with and without ocular disease is warranted.

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Section: Search Strategymentioning

confidence: 88%

Section: -55mentioning

confidence: 99%

Hydration, fluid regulation and the eye: in health and disease

Sherwin

Kokavec

Thornton

2015

Clinical Exper Ophthalmology

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“…A common practice among endurance riders is to provide electrolytes, beet pulp, and other modalities to encourage hydration prior to a ride to improve equine metabolic status during a ride and prevent dehydration. These techniques may result in over hydration and affect baseline IOP in the opposite manner as that proposed with dehydration and IOP reduction …”

Section: Discussionmentioning

confidence: 99%

“…Three leading theories include decreased blood pH, elevated blood lactate, or elevated plasma osmolarity, with the latter being most supported by current literature and the only one present in aerobic as well as anaerobic exercise . Several studies have reported that dehydration causes an increase in plasma osmolality, which in turn may lower the rate of aqueous humor formation and result in documented IOP reduction through osmotic dehydration of the globe, reduced aqueous ultrafiltration, or a hypothalamic reflex …”

Section: Introductionmentioning

confidence: 97%

Intraocular pressure changes in equine athletes during endurance competitions

Allbaugh

Keil²,

2014

Veterinary Ophthalmology

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“…V˙O 2max and maximum heart rate were determined as per standard laboratory procedure [9]. Following a warm up period, participants determined a comfortable running speed for use during the test.…”

Section: Methodsmentioning

confidence: 99%

Physiological Tolerance Times while Wearing Explosive Ordnance Disposal Protective Clothing in Simulated Environmental Extremes

Stewart

Worringham

et al. 2014

PLoS ONE

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Explosive ordnance disposal (EOD) technicians are required to wear protective clothing to protect themselves from the threat of overpressure, fragmentation, impact and heat. The engineering requirements to minimise these threats results in an extremely heavy and cumbersome clothing ensemble that increases the internal heat generation of the wearer, while the clothing’s thermal properties reduce heat dissipation. This study aimed to evaluate the heat strain encountered wearing EOD protective clothing in simulated environmental extremes across a range of differing work intensities. Eight healthy males [age 25±6 years (mean ± sd), height 180±7 cm, body mass 79±9 kg, V˙O2max 57±6 ml.kg−1.min−1] undertook nine trials while wearing an EOD9 suit (weighing 33.4 kg). The trials involved walking on a treadmill at 2.5, 4 and 5.5 km⋅h−1 at each of the following environmental conditions, 21, 30 and 37°C wet bulb globe temperature (WBGT) in a randomised controlled crossover design. The trials were ceased if the participants’ core temperature reached 39°C, if heart rate exceeded 90% of maximum, if walking time reached 60 minutes or due to fatigue/nausea. Tolerance times ranged from 10–60 minutes and were significantly reduced in the higher walking speeds and environmental conditions. In a total of 15 trials (21%) participants completed 60 minutes of walking; however, this was predominantly at the slower walking speeds in the 21°C WBGT environment. Of the remaining 57 trials, 50 were ceased, due to attainment of 90% maximal heart rate. These near maximal heart rates resulted in moderate-high levels of physiological strain in all trials, despite core temperature only reaching 39°C in one of the 72 trials.

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The intraocular pressure response to dehydration: a pilot study

Cited by 17 publications

References 10 publications

Hydration, fluid regulation and the eye: in health and disease

Hydration, fluid regulation and the eye: in health and disease

Intraocular pressure changes in equine athletes during endurance competitions

Physiological Tolerance Times while Wearing Explosive Ordnance Disposal Protective Clothing in Simulated Environmental Extremes

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