The intramedullary course of the upper five, cervical, dorsal root fibers in the rabbit

Yee, James; Corbin, Kendall B.

doi:10.1002/cne.900700209

Cited by 31 publications

(4 citation statements)

References 10 publications

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“…Sparse primary afferent projec tions to the spinal vestibular nucleus from rostral cervical segments have been reported for the rabbit [Yee and Corbin, 1939] and cat [Escolar, 1948], Recent studies on the cat have not supported these projections [Rustioni and Macchi, 1968;Keller and Hand, 1970]. In the present study, sparse degeneration from C0 to T, segments was present in the cattdolateral part of the spinal vestibular nucleus.…”

Section: Discussionsupporting

confidence: 57%

“…The distribution of cervical and upper thoracic primary afferents to the dorsal column nuclei (DCN) has been reported for reptiles [Joseph and Whitlock, 1968], rodents [Yee and Corbin, 1939;Davidson and Smith, 1972], carnivores [Liu, 1956;Walberg, 1966;Rustioni and Macchi, 1968;Keller and Hand, 1970;Imai and Kusama, 1969] and primates [Ferraro and Barrera, 1935b;Corbin et al, 1937;Walker and Weaver, 1942;Shriver et al, 1968]. Most of our knowledge of the organization of primary afferents to the DCN is based on reports on ani mals which demonstrate essentially a quadripedal form of locomotion [Andersen et al, 1964;Nord, 1967;J abbur and Banna, 1970;Camp bell et al, 1974].…”

Section: Introductionmentioning

confidence: 99%

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Dorsal Column Nuclei in a Prosimian Primate (Galago senegalensis)

Albright¹,

Haines²

1978

Brain Behav Evol

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The morphology and brachial cord primary afferent projections of the cuneate and lateral cuneate nuclei have been studied in the lesser bushbaby. The cuneate nucleus was divided into three regions. From caudal to rostral these were the large cell, cell column and rostral regions. Primary afferents from C₂, C₄, C₆, C₇, C₈, T₁ and T₃ terminated within distinct partially overlapping terminal zones in the ipsilateral large cell and cell column regions of the cuneate nucleus (CN) and the lateral cuneate nucleus (LCN). Segmentotopic was the greatest in the rostal region of the CN due to a more diffuse projection pattern. In the LCN, the transverse terminal fields appeared as curved mediolaterally oriented laminae. In each case, ascending fibers of passage from C₄, C₆ and C₇ in the cuneate fasciculus were organized so that two distinct fiber laminae were present. The separation of fibers and the formation of the two ascending laminae was completed either within two segments rostral to their respective level of entry (for C₆ and C₇ lesions) or in the caudal medulla (for C₄ lesion). For each of these segments, the laminae consisted of a small dorsomedial one and a larger lateral one. The organization of primary afferents from one segment into two ascending fiber laminae in the cuneate fasciculus was reflected in a differential termination pattern within both the CN and LCN. The results of this study were discussed relative to earlier anatomical and physiological studies on the DCN in other animals.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Dorsal Column Nuclei in a Prosimian Primate (Galago senegalensis)

Albright¹,

Haines²

1978

Brain Behav Evol

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“…The motivation for choosing this particular nerve was twofold: First, the sensory innervation of the occipital region and posterior aspect of the neck was for a long time an active area of research to understand the role of its extero‐ and proprioceptive contribution to postural control and coordination of eye movements. Not surprisingly, the organization of central projections from upper cervical spinal nerves was profusely investigated with every anatomical or functional method that came to life along the last century (Bolton & Ray, ; Escolar, ; Kerr, ; Kerr & Olafson, ; Neuhuber & Zenker, ; Pfaller & Arvidsson, ; Yee & Corbin, ). Yet, only in two studies, using transganglionic transport of HRP, were the GON and/or its central projections specifically examined (Neuhuber & Zenker, ; Scheurer et al, ).…”

Section: Discussionmentioning

confidence: 99%

The greater occipital nerve and its spinal and brainstem afferent projections: A stereological and tract‐tracing study in the rat

García-Magro

Martín

Negredo

et al. 2018

J of Comparative Neurology

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The neuromodulation of the greater occipital nerve (GON) has proved effective to treat chronic refractory neurovascular headaches, in particular migraine and cluster headache. Moreover, animal studies have shown convergence of cervical and trigeminal afferents on the same territories of the upper cervical and lower medullary dorsal horn (DH), the so-called trigeminocervical complex (TCC), and recent studies in rat models of migraine and craniofacial neuropathy have shown that GON block or stimulation alter nociceptive processing in TCC. The present study examines in detail the anatomy of GON and its central projections in the rat applying different tracers to the nerve and quantifying its ultrastructure, the ganglion neurons subserving GON, and their innervation territories in the spinal cord and brainstem. With considerable intersubject variability in size, GON contains on average 900 myelinated and 3,300 unmyelinated axons, more than 90% of which emerge from C ganglion neurons. Unmyelinated afferents from GON innervates exclusively laminae I-II of the lateral DH, mostly extending along segments C . Myelinated fibers distribute mainly in laminae I and III-V of the lateral DH between C and C and, with different terminal patterns, in medial parts of the DH at upper cervical segments, and ventrolateral rostral cuneate, paratrigeminal, and marginal part of the spinal caudal and interpolar nuclei. Sparse projections also appear in other locations nearby. These findings will help to better understand the bases of sensory convergence on spinomedullary systems, a critical pathophysiological factor for pain referral and spread in severe painful craniofacial disorders.

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“…The morphology of the vestibular com plex of Galago conforms to the general pattern as seen in opossum [31,61], cat [12], rabbit [69], rat [39], pig [8], Tarsius [64], monkey [15,38,40,45], and man [7,54], A striking feature of the Galago ves tibular complex, however, is its large size relative to the total size of the brain stem [present study, 24, 27], A similar differen tial was also reported by Tilney [64] who believed that this characteristic in Tarsius was related to the hopping locomotor style of this primate. A similar suggestion could be made for Galago since this primate also has a well-developed saltatory locomotor style [44],…”

Section: The Galago Vestibular Nuclei and Associated Subgroupsmentioning

confidence: 99%

The Vestibular Complex in a Prosimian Primate (Galago senegalensis): Morphology and Spinovestibular Connections (Part 2 of 2)

Rubertone

Haines

1982

Brain Behav Evol

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The morphology of, and distribution of spinal afferents to, the vestibular complex of a prosimian primate (lesser bushbaby, Galago senegalensis) were studied using cytoarchitectural, myeloarchitectural and selective silver impregnation methods. The vestibular complex of Galago consists of superior (SVN), lateral (LVN), medial (MVN) and spinal (SpVN) nuclei, each nucleus having cell populations of characteristic size, shape and distribution within its borders. There is morphological and experimental evidence for the existence of subgroups f, 1, x, y and z and a hitherto undescribed subgroup located in dorsomedial portions of the rostral two-thirds of the MVN. Following partial or complete hemisections at cord levels C₁-L₆ brain stem sections were impregnated according to the method of Fink and Heimer. Preterminal debris is concentrated mainly in subgroups x and z, relatively sparse in adjacent SpVN and moderate to sparse in LVN and MVN following hemisections at upper and mid-cervical levels. Axonal debris is noticeably absent from the MVN after lesions below the C₈ spinal level; this indicates that the MVN receives spinal input from cervical levels only. Following lesions at C₈ and progressively lower spinal levels, degeneration was found primarily in subgroups x and z and in LVN and SpVN although in lesser amounts; as lesions were placed at progressively lower levels there was a proportionate decrease in the amount of axonal debris found in these respective nuclei. No degeneration was found in SVN following lesions at any spinal level.

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The intramedullary course of the upper five, cervical, dorsal root fibers in the rabbit

Cited by 31 publications

References 10 publications

Dorsal Column Nuclei in a Prosimian Primate <i>(Galago senegalensis)</i>

Dorsal Column Nuclei in a Prosimian Primate <i>(Galago senegalensis)</i>

The greater occipital nerve and its spinal and brainstem afferent projections: A stereological and tract‐tracing study in the rat

The Vestibular Complex in a Prosimian Primate <i>(Galago senegalensis): </i>Morphology and Spinovestibular Connections (Part 2 of 2)

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