The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice
Maxime Vande Vyver,
Louise Daeninck,
Gino De Smet
et al.
Abstract:ObjectivesEpileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ1-42) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these Aβ1-42 oligomers cause the increased seizure susceptibility in vivo in people with AD and in AD animal models, nor via which mechanisms it would do so. We investigated this question by injecting Aβ1-42 oligomers intracerebrall… Show more
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