The Intracellular Phase of Fat Absorption

Brindley, David N.

doi:10.1007/978-1-4684-3336-4_2

Cited by 32 publications

(14 citation statements)

References 225 publications

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“…The present paper demonstrates that adipose tissue, like the small intestine (Brindley, 1974), can synthesize glycerolipids from glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerols.…”

Section: Discussionmentioning

confidence: 53%

The glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerol pathways of glycerolipid synthesis in rat adipose-tissue homogenates

Dodds¹,

Gurr²,

Brindley³

1976

Biochemical Journal

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1. Fat-free homogenates from the epididymal fat-pads ofrats were used to measure the rate of palmitate esterification with different substrates. The effectiveness of the acyl acceptors decreased in the order glycerol phosphate, dihydroxyacetone phosphate, 2-octadecenylglycerol and 2-hexadecylglycerol. 2. Glycerol phosphate and dihydroxyacetone phosphate inhibited their rates of esterification in a mutually competitive manner. 3. The esterification of glycerol phosphate was also inhibited in a partially competitive manner by 2-octadecenylglycerol and to a lesser extent by 2-hexadecylglycerol. However, glycerol phosphate did not inhibit the esterification of 2-octadecenylglycerol. 4. The esterification of dihydroxyacetone phosphate and 2-hexadecylglycerol was more sensitive to inhibition by clofenapate than was that of glycerol phosphate. Norfenfluramine was more effective in inhibiting the esterification of 2-hexadecylglycerol than that of glycerol phosphate or dihydroxyacetone phosphate. 5. It is concluded that rat adipose tissue can synthesize glycerolipids by three independent routes.

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Section: Discussionmentioning

confidence: 53%

The glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerol pathways of glycerolipid synthesis in rat adipose-tissue homogenates

Dodds¹,

Gurr²,

Brindley³

1976

Biochemical Journal

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“…This has been described previously in the animal. In view of the metabolic pathway studied, such a fact indicates a high turnover rate of PL, especially of phosphatidate (9,11,12,15,17). There was a low but significant incorporation of palmitate into MG.…”

Section: Discussionmentioning

confidence: 99%

“…Much experimental work has been devoted to the cellular phase of lipid absorption and transport (9). But only limited progress has been made in the clinical field during the last 10 years (7,12).…”

mentioning

confidence: 99%

Quantitative Studies <i>in vitro </i>on Uptake and Esterification of Palmitate into Human and Rat Jejunal Mucosa

Sueur¹,

Cerf²,

Costanzo³

et al. 1977

Digestion

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Quantitative incorporation and esterification of (9–10) ³H palmitate into jejunal mucosa was studied in vitro comparatively on human biopsies and on everted rings of rat intestine following various incubation times. This procedure is fitted for investigation of the glycerophosphate pathway. Quantitatively the total uptake of palmitate was similar in man and rat. But the distribution among the various esterified fractions was different in animal and man and different again in coeliac disease. Notwithstanding incorporation of palmitate into triglyceride the fatty acid composition of mucosal triglyceride showed little or no modification.

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“…The subject oflipid absorption and metabolism has been extensively reviewed (3)(4)(5)(6)(7)(8)(9)(10)(11), including the physical chemistry of the process (8,9) and possible metabolic control points (5,6,10). The present discussion briefly summarizes the current understandingof the field and integrates it with some new in vivo and in vitro data gathered with intact cells, which support some of the earlier concepts and dispute others.…”

Section: Introductionmentioning

confidence: 99%

Lipid absorption and metabolism.

Kuksis¹,

Shaikh²,

Hoffman³

1979

Environ Health Perspect

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Metabolic processes occurring within the mucosal cell are critical in determining results of interactions between environmental agents and the alimentary tract. The absorption, metaboUsm, and transport of lAds affects most those agents which are lipid soluble. The understanding of the process involved in lipid absorption and transport is therefore important for both appreciation of the mechanism of uptake of these twdns and for an effective interference with it. Most of the detailed mechanisms of lipid absorption and trnport have been proposed from in vitro studies with soluble cell-free systems. The present review integrates these results with recent in vivo and in vitro findings with intact animal tissues and isolated mucesal cells. While there is much general agreement occasional startling differences are also observed, which may have a bearing on the mechanism of normal fat absorption and on the understanding of the transport of the fat-soluble toxins across the mucosal villus cell.

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The Intracellular Phase of Fat Absorption

Cited by 32 publications

References 225 publications

The glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerol pathways of glycerolipid synthesis in rat adipose-tissue homogenates

The glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerol pathways of glycerolipid synthesis in rat adipose-tissue homogenates

Quantitative Studies <i>in vitro </i>on Uptake and Esterification of Palmitate into Human and Rat Jejunal Mucosa

Lipid absorption and metabolism.

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