The intracellular life of Acinetobacter baumannii

Maure, Alexandra; Robino, Etienne; Henst, Charles Van der

doi:10.1016/j.tim.2023.06.007

Cited by 10 publications

(10 citation statements)

References 104 publications

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“…Recent reports describe and support the facultative intracellular lifestyle of A. baumannii (30). Indeed, some isolates have been shown to survive and even proliferate inside eukaryotic cells (31) and macrophages (32).…”

Section: Discussionmentioning

confidence: 97%

The polysaccharide capsule ofAcinetobacter baumanniiaffects bacterial adhesion and natural transformation

Whiteway,

de Pillecyn,

Maure

et al. 2024

Preprint

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Acinetobacter baumannii is an important threat worldwide due to its ability to acquire antibiotic resistance and survive harsh conditions. The polysaccharide capsule represents a major virulence and resistance asset. How the capsular polysaccharides barrier impacts bacterial adhesion remains to be investigated in A. baumannii. We characterized capsule mutants of the commonly used AB5075 strain. We assessed how these different capsule mutants adhere to biotic (bacterial and eukaryotic cells) and abiotic surfaces (polystyrene). We confirmed our observations using modern and relevant clinical isolates characterized by different capsule types and capsulation levels. Strains with low capsulation levels systematically depicted increased adhesion compared to capsulated strains, and mucoid isolates showed minimal adhesion. These results show capsule production in A. baumannii affects adhesion to various surfaces. We also determined that the presence/absence of A. baumannii capsule influences its natural transformability. This illustrates the importance of the trade-off of capsule production in A. baumannii.

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Section: Discussionmentioning

confidence: 97%

The polysaccharide capsule ofAcinetobacter baumanniiaffects bacterial adhesion and natural transformation

Whiteway,

de Pillecyn,

Maure

et al. 2024

Preprint

Self Cite

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“…Through a wide range of pan-genomic studies, it has been recognized that A. baumannii is an open pan-genomic bacterial pathogen; hence, A. baumannii encompasses a variety of virulence factors with different functions and activities. Because of the importance of these virulence factors, Table 1 shows a complete package of the identified virulence factors together with the related genes [ 3 , 68 , 69 ].…”

Section: Virulencementioning

confidence: 99%

“…OMPs are important bacterial virulence factors in A. baumannii strains for bacterial adherence in the human host cells ( Table 1 and Table 2 , Figure 2 ). OmpA contributes to bacterial adhesion ( A. baumannii ATCC17978 and ATCC19606) to the epithelial cells [ 69 ]. OmpA is capable of attaching to human host integrins, junctional adherence proteins, fibronectin and cytoskeleton.…”

Section: Virulencementioning

confidence: 99%

“…This strategy helps the bacterial cells of A. baumannii to invade the epithelial cells of the host body. Therefore, the overexpression of OMPs in A. baumannii is presumed to be an effective means for bacterial adhesion to human host cells as a part of bacterial virulence and pathogenesis [ 69 , 108 , 109 ].…”

Section: Virulencementioning

confidence: 99%

“…Because of the high diversity of pili in Gram-negative bacteria, they have been categorized into five different groups: chaperone-usher pili (CUP), curli fimbriae, type IV pili, type V pili, and conjugative type IV secretion pili ( Table 2 ). The CUP pili are effective virulence factors in clinical isolates of A. baumannii strains because of their capability to adhere to biotic and abiotic surfaces in human patients with different infectious diseases like urinary tract infections [ 69 , 132 , 133 ]. The immunogenic Csu pili ( Figure 2 ) belongs to type I CUP and has been detected in A. baumannii strains.…”

Section: Virulencementioning

confidence: 99%

See 2 more Smart Citations

Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove for Acinetobacter baumannii

Karampatakis,

Tsergouli,

Behzadi

2024

Antibiotics

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Acinetobacter baumannii is a Gram-negative pathogen responsible for a variety of community- and hospital-acquired infections. It is recognized as a life-threatening pathogen among hospitalized individuals and, in particular, immunocompromised patients in many countries. A. baumannii, as a member of the ESKAPE group, encompasses high genomic plasticity and simultaneously is predisposed to receive and exchange the mobile genetic elements (MGEs) through horizontal genetic transfer (HGT). Indeed, A. baumannii is a treasure trove that contains a high number of virulence factors. In accordance with these unique pathogenic characteristics of A. baumannii, the authors aim to discuss the natural treasure trove of pan-genome and virulence factors pertaining to this bacterial monster and try to highlight the reasons why this bacterium is a great concern in the global public health system.

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Exploring the evolutionary and pathogenic role of Acinetobacter baumannii biofilm-associated protein (Bap) through in silico structural modeling

Upmanyu,

Kumar,

Rizwanul Haque

et al. 2024

Arch Microbiol

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The intracellular life of Acinetobacter baumannii

Cited by 10 publications

References 104 publications

The polysaccharide capsule ofAcinetobacter baumanniiaffects bacterial adhesion and natural transformation

The polysaccharide capsule ofAcinetobacter baumanniiaffects bacterial adhesion and natural transformation

Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove for Acinetobacter baumannii

Exploring the evolutionary and pathogenic role of Acinetobacter baumannii biofilm-associated protein (Bap) through in silico structural modeling

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