The intracellular C-terminal domain of mGluR6 contains ER retention motifs

Shimohata, Atsushi; Rai, Dilip; Akagi, Tomonori; Usui, Sumiko; Ogiwara, Ikuo; Kaneda, Makoto

doi:10.1016/j.mcn.2023.103875

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2024

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“…Like other mGluRs ( 39 , 40 , 41 , 42 , 43 ), mGluR6 has been reported to form dimers ( 21 ), though no structures of mGluR6 have yet been reported. Single particle cryo-EM structures of full-length mGluR2, mGluR3, mGluR4, mGluR5, and mGluR7 ( 40 , 41 , 43 , 44 , 45 ) revealed that in most cases, the dimer interface in the inactive state is formed primarily by the LBD, whereas in the active state the CRD and TM may also associate.…”

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confidence: 99%

“…Previously, we found that regions in the LBD were necessary for both ELFN1 binding and dendritic tip localization in BCs, but not plasma membrane (PM) trafficking in heterologous cells ( 18 ). The small C-terminal cytoplasmic domain was dispensable for dendritic tip localization in BCs, though deletions in this domain were reported to affect PM trafficking ( 18 , 20 , 21 ).…”

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confidence: 99%

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