“…Like other mGluRs ( 39 , 40 , 41 , 42 , 43 ), mGluR6 has been reported to form dimers ( 21 ), though no structures of mGluR6 have yet been reported. Single particle cryo-EM structures of full-length mGluR2, mGluR3, mGluR4, mGluR5, and mGluR7 ( 40 , 41 , 43 , 44 , 45 ) revealed that in most cases, the dimer interface in the inactive state is formed primarily by the LBD, whereas in the active state the CRD and TM may also associate.…”