The intracarotid etomidate Wada test: A 54-patient series

Passarelli, Valmir; Pinto, Lécio Figueira; Jorge, Carmen Lisa; Puglia, Paulo; Adda, Carla Cristina; Wen, Hung-Tzu; Castro, Luiz Henrique Martins

doi:10.1016/j.yebeh.2014.08.028

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…Wada test was performed on all patients in the surgical group using etomidate due to sodium amytal unavailability, according to a published institutional protocol, which is safe and effective. 21 Strength and language were tested prior to anesthetic injection. Both hemispheres were sequentially tested, starting with injection on the HS side.…”

Section: Wada Testingmentioning

confidence: 99%

Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery

Castro‐Lima,

Passarelli,

Ribeiro

et al. 2023

Epilepsia Open

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ObjectiveTo compare memory outcomes after surgery for unilateral Hippocampal Sclerosis (HS) associated epilepsy in patients with unilateral and bilateral ictal electrographic involvement.MethodsWe prospectively evaluated HS patients, aged 18 to 55 years and IQ≥70. Left (L) and right (R) surgical groups underwent noninvasive video‐EEG monitoring and Wada test. We classified patients as Ipsilateral if ictal EEG was restricted to the HS side, or Bilateral, if at least one seizure onset occurred contralaterally to the HS, or if ictal discharge evolved to the opposite temporal region. Patients who declined surgery served as controls. Memory was evaluated on two occasions with Rey Auditory‐Verbal Learning Test and Rey Visual‐Design Learning Test. Baseline neuropsychological test scores were compared between groups. Pre‐ and postoperative scores were compared within each group. Reliable Change Index Z‐scores (RCI) were obtained using controls as references, and compared between surgical groups.ResultsWe evaluated 64 patients. Patients were classified as: L‐Ipsilateral(9), L‐Bilateral(15), L‐Control(9), R‐Ipsilateral(10), R‐Bilateral (9), R‐Control(12). On preoperative evaluation, memory performance did not differ among surgical groups. Right HS patients did not present postoperative memory decline. L‐Ipsilateral group presented postoperative decline on immediate (p=0.036) and delayed verbal recall (p=0.011), while L‐Bilateral did not decline. L‐Ipsilateral had lower RCI Z‐scores, indicating delayed verbal memory decline compared to L‐Bilateral (p=0.012).SignificanceDominant HS patients with bilateral ictal involvement presented less pronounced postoperative verbal memory decline compared to patients with exclusive ipsilateral ictal activity. Surgery was indicated in these patients regardless of memory impairment on neuropsychological testing, since resection of the left sclerotic hippocampus could result in cessation of contralateral epileptiform activity, and, therefore, improved memory function.

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Section: Wada Testingmentioning

confidence: 99%

Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery

Castro‐Lima,

Passarelli,

Ribeiro

et al. 2023

Epilepsia Open

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show abstract

“…Já as displasias corticais podem ser de difícil identificação, mesmo com protocolos específicos de RM 22 . O uso de métodos diagnósticos adjuvantes pode ser necessário, tanto de imagem como o uso de tomografia por emissão de posítrons/fóton único (PET/SPECT-TC) cerebral, bem como exames funcionais como métodos de vídeo-eletroencefalograma (VEEG) invasivos, tanto com placas subdurais como com eletródios profundos, além da utilização de testes para identificação da lateralização da linguagem como o teste do amital sódico (WADA) 23 .…”

Section: Methodsunclassified

Decorticação frontal: descrição anátomo-cirúrgica de nova técnica de lobectomia frontal sem a abertura do corno frontal do ventrículo lateral

Róz¹,

Maria²

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“…Este protocolo já vem sendo utilizado na instituição, mostrando-se seguro e eficaz (Passarelli et al, 2014). Antes da injeção do anestésico, são testados força e linguagem.…”

Section: Teste De Wadaunclassified

Impacto da cirurgia de epilepsia no desempenho cognitivo de pacientes com esclerose mesial temporal unilateral

Filho¹,

Castro²

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The intracarotid etomidate Wada test: A 54-patient series

Cited by 9 publications

References 20 publications

Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery

Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery

Decorticação frontal: descrição anátomo-cirúrgica de nova técnica de lobectomia frontal sem a abertura do corno frontal do ventrículo lateral

Impacto da cirurgia de epilepsia no desempenho cognitivo de pacientes com esclerose mesial temporal unilateral

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