The Intestino-Intestinal Inhibitory Reflex: Threshold Variations, Sensitization and Summation

Peterson, Clare G.; Youmans, W. B.

doi:10.1152/ajplegacy.1945.143.3.407

Cited by 17 publications

(9 citation statements)

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“…with a stimulus of low intcnsity it is strictly segmental, but a higher intensity it engages the sympathetic outflow of' several segmrnts (6). This is probably an expression of the temporal and spatial facilitation mechanisms which have been demonstrated for the reflex (17).…”

Section: Functional Considerationsmentioning

confidence: 65%

Epidural Fentanyl Counteracts Sympathetic Gastric Inhibition

Lisander

Stenqvist

1985

Acta Anaesthesiol Scand

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Postoperative paralytic ileus is in part mediated by the sympathetic gastrointestino-gastrointestinal (GI-GI) reflex. The modulation of this reflex by epidural fentanyl (50 micrograms) was studied in chloralose-anesthetized, ventilated cats. The vagi were cut in the neck but could be efferently stimulated. Gastric volume, arterial pressure and heart rate were followed and the GI-GI reflex was elicited by intestinal distension, mesenteric afferent nerve stimulation or heating or capsaicin administered intra-arterially to an intestinal loop. Epidural fentanyl enhanced the gastric contraction response to efferent vagal stimulation and considerably counter-acted the GI-GI reflex inhibition of vagally induced tone. These effects were reversed by epidural naloxone (10 micrograms). In contrast, 50 micrograms of fentanyl i.v. only enhanced the effect of vagal stimulation but had no influence on the inhibitory GI-GI reflex responses. Apparently, epidural fentanyl may inhibit the GI-GI reflex by a spinal point of action.

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Section: Functional Considerationsmentioning

confidence: 65%

Epidural Fentanyl Counteracts Sympathetic Gastric Inhibition

Lisander

Stenqvist

1985

Acta Anaesthesiol Scand

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“…19 Finally, the use of a longer bag or the simultaneous distension of another segment of the gut may have enhanced a reflex inhibition as a result of the spatial summation of the stimulus. 20,21 On the contrary, the mean increase in abdominal girth observed at the end of the distension was about 1.1 mm during the fast and 0.8 mm during the slow distension, both of which are compatible with the passive expansion of abdominal girth as a result of rectal distension. Assuming that the abdominal cavity is a cylinder 22 with a radius of 12 cm and a fixed height of 28 cm, its volume can be calculated using the formula pr 2 · h; the addition of an incompressible volume of 150 mL inside the cylinder should increase its circumference by 4 mm.…”

Section: Figurementioning

confidence: 77%

“…Furthermore, gut distension cranial to the rectum can enhance the effect of the rate of distension, although the finding that the proximal jejunum relaxes in response to the distension of the distal jejunum but not vice versa suggests that the functional organization of the interconnecting reflex circuits favours cranial over caudal inhibition 19 . Finally, the use of a longer bag or the simultaneous distension of another segment of the gut may have enhanced a reflex inhibition as a result of the spatial summation of the stimulus 20,21 …”

Section: Discussionmentioning

confidence: 99%

Effect of rectal distension on abdominal girth

Marino

Ogliari

Basilisco

2004

Neurogastroenterology Motil

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It has been postulated that a viscerosomatic reflex activated by gut distension and inhibiting abdominal wall muscle tone may be one of the mechanisms underlying functional abdominal distension. Any demonstration of such a reflex has to take into account the fact that gut distension may increase abdominal girth as a result of volume displacement. As biomechanical and sensory rectal responses vary at different rates of rectal distension, we hypothesized that different rates of rectal distension might reveal different changes in abdominal girth. Abdominal girth was continuously recorded in 14 healthy subjects using a previously validated extensometer. The rectal distensions were made in a randomized order at rates of 100 mL min(-1) or 10 mL min(-1) up to 150 mL, and sham distensions were used as controls. An increase in abdominal girth was observed at the end of both distensions (P

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“…The intestinal movements are regulated in situ reflexively via the extrinsic and intrinsic nerves. As regard to the effect of the extrinsic reflex of the small intestine only an inhibitory one was observed (10,18,20,22,23), while the effects of the intrinsic reflex have been of a complicated character as shown in the following historical survey.…”

mentioning

confidence: 84%