The intestinal absorption of some dipeptides

The effects of adrenalectomy and fasting on intestinal function in the rat

“…of this solution for 30 min at 380 C. Sugars, amino acids or peptides were present in the mucosal or serosal fluids as described subsequently. At the end of the experimental period determinations of sugars, amino acids or peptides were made in the mucosal fluid, serosal fluid and gut wall, and transports were calculated as described by Parsons, Smyth & Taylor (1958) or when peptides were used as described by Newey & Smyth (1959).…”

“…Glycine was estimated after de-proteinization by the method of Alexander, Landwehr & Seligman (1945) as modified by Christensen, Riggs & Ray (1951). Glycyl-glycine was determined by estimating free and bound glycine as described by Newey & Smyth (1959).…”

Blood plasma free amino acid studies in swine

“…Parshin and Rubel (1951) reported evidence that very small amounts of peptides, if any, are actually absorbed through the intestinal wall and carried as such in the blood stream. This finding has been confirmed more recently by Newey and Smyth (1959), who found that only free amino acids are found in the serosal side of the intestine after introducing peptides in the intestinal lumen, both in _in vivo and_in vitro absorption techniques.…”

Absorption of proteins

“…There are 400 possible dipeptides of dietary amino acids and 8000 possible tripeptides. The three full-scale papers that I have consulted (Agar, Hird & Sidhu, 1954; Newey & Smyth, 1959; Wiggans & Johnston, 1959) concern themselves with six dipeptides and one tripeptide.…”