The intertwined roles of circadian rhythmsand neuronal metabolism fueling drug reward and addiction

Freyberg, Zachary; Logan, Ryan W.

doi:10.1016/j.cophys.2018.08.004

Cited by 13 publications

(6 citation statements)

References 147 publications

(148 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functionally, previous work in the brain also showed that bromocriptine functions as an α 2A -AR agonist in the chicken pineal gland to suppress circadian increases in melatonin synthesis ( Zawilska and Iuvone, 1990 ). Bromocriptine’s actions on adrenergic receptors may therefore offer a novel mechanism for the drug’s ability to modify circadian regulation of catecholamine signaling in the CNS and periphery ( Cincotta et al., 1993 ; Freyberg and Logan, 2018 ; Holt et al., 2010 ; Wei et al., 2020 ). Similarly, in adipocytes, bromocriptine diminishes adipogenesis, lipogenesis, and obesity-related inflammation via α 2A -AR agonism ( Mukherjee and Yun, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

et al. 2022

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

et al. 2022

Self Cite

View full text Add to dashboard Cite

“…Moreover, fentanyl self-administration in Sprague-Dawley rats has also been shown to increase expression of cytokines (e.g., interleukin (IL)1β, IL5), chemokines, tumor necrosis factor α (TNFα), and interferon proteins (e.g., IFNβ and IFNγ) in the NAc 68 . Our mouse proteomic data add to these previous studies, furthering a need for functional investigation into immune-and metabolic-related mechanisms underlying OUD and potential interactions with the circadian system [69][70][71][72] .…”

Section: Discussionmentioning

confidence: 58%

Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome

Ketchesin

Becker‐Krail

Xue

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Substance use disorders (SUDs) are associated with disruptions in sleep and circadian rhythms that persist during abstinence and may contribute to relapse risk. Repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (NAc), a brain region central to reward and motivation. Previous studies have identified rhythm alterations in the transcriptome of the NAc and other brain regions following the administration of psychostimulants or opioids. However, little is known about the impact of substance use on the diurnal rhythms of the proteome in the NAc. We used liquid chromatography coupled to tandem mass spectrometry-based (LC-MS/MS) quantitative proteomics, along with a data-independent acquisition (DIA) analysis pipeline, to investigate the effects of cocaine or morphine administration on diurnal rhythms of proteome in the mouse NAc. Overall, our data reveals cocaine and morphine differentially alters diurnal rhythms of the proteome in the NAc, with largely independent differentially expressed proteins dependent on time-of-day. Pathways enriched from cocaine altered protein rhythms were primarily associated with glucocorticoid signaling and metabolism, whereas morphine was associated with neuroinflammation. Collectively, these findings are the first to characterize the diurnal regulation of the NAc proteome and demonstrate a novel relationship between phase-dependent regulation of protein expression and the differential effects of cocaine and morphine on the NAc proteome.

show abstract

“…The most significant finding of our current study was that the circadian entrainment pathway, which plays an important role in helping organisms cope with dynamic environmental changes and maintain survival with adaptive behavior, was involved in susceptibility to MA addiction (30). In mammals, the circadian entrainment pathway consists of two parts.…”

Section: Analysis Of Dmr Data Inferred the Role Of The Circadian Entrmentioning

confidence: 61%

Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities

Liu

Luo²,

Dong³

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

This paper aimed to explore the genome-wide DNA methylation status of methamphetamine (MA) abusers with different qualities to addiction and to identify differentially methylated candidate genes. A total of 207 male MA abusers with an MA abuse frequency of ≥10 times and an MA abuse duration of ≥1 year were assigned to the high MA addiction quality group (HMAQ group; 168 subjects who met the diagnostic criteria for MA dependence according to the DSM-IV) or to the low MA addictive quality group (LMAQ group; 39 subjects who did not meet the criteria for MA dependence). In addition 105 healthy controls were recruited. Eight HMAQ subjects, eight LMAQ subjects, and eight healthy controls underwent genome-wide DNA methylation scans with an Infinium Human Methylation 450 array (Illumina). The differentially methylated region (DMR) data were entered into pathway analysis, and the differentially methylated position (DMP) data were screened for candidate genes and verified by MethyLight qPCR with all samples. Seven specific pathways with an abnormal methylation status were identified, including the circadian entrainment, cholinergic synapse, glutamatergic synapse, retrograde endocannabinoid signaling, GABAergic synapse, morphine addiction and PI3K-Akt signaling pathways. SLC1A6, BHLHB9, LYNX1, CAV2, and PCSK9 showed differences in their methylation levels in the three groups. Only the number of methylated copies of CAV2 was significantly higher in the LMAQ group than in the HMAQ group. Our findings suggest that the circadian entrainment pathway and the caveolin-2 gene may play key roles in MA addiction quality. Further studies on their functions and mechanisms will help us to better understand the pathogenesis of MA addiction and to explore new targets for drug intervention.

show abstract

The intertwined roles of circadian rhythmsand neuronal metabolism fueling drug reward and addiction

Cited by 13 publications

References 147 publications

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome

Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities

Contact Info

Product

Resources

About