The interrelationships of radioimmunoassayable urinary albumin, renal function and diabetes

Suzuki, Masao; Waldeck, N; Nd, Vaziri; Ascher, Michael S.; Simpkins, Henry; Worcester, Beverly; Charles, M. Arthur

doi:10.1016/s0168-8227(86)80028-6

Cited by 2 publications

(2 citation statements)

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“…Diabetics (type I and type II) showed a mean AER significantly higher than normals even after excluding the microalbuminuric subjects ( Figure 3 and Table 2), because 27% of diabetics exceeded the upper normal limit (Figure 3). A weak correlation between the diabetes duration and the AER was found only in type I patients, in accordance with other authors (26,27,29). We observed no correlation between AER and HbAlc in diabetics possibly due to their narrow range of glycated hemoglobin.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Urinary albumin excretion in normal subjects and in diabetic patients measured by a radioimmunoassay: Methodological and clinical aspects

Giampietro

Miccoli

Clerico

et al. 1988

Clinical Biochemistry

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We have developed a radioimmunoassay method (RIA) to measure urinary albumin excretion. We determined the albumin excretion rate (AER) (micrograms/min) of 122 healthy subjects and 145 diabetic patients (115 type I, 30 type II). The results indicate that the RIA is sensitive (0.39 +/- 0.08 mg/L), precise (CV 5-8%), and gives reliable results on previously frozen urine samples. The distribution of the AER values in healthy subjects and diabetic patients was not normal. It was normalized by log or square-root transformation of the data. Seventy-three percent of diabetic patients lay within the normal range (0.6-10.6 micrograms/min). Twenty percent could be considered "at risk" to develop overt diabetic nephropathy because their albuminuria exceeded a threshold level of 15 micrograms/min chosen previously as the cutoff value for microalbuminuria. We found no correlation between AER and glycated hemoglobin, and only a weak correlation between AER and diabetes duration in type I diabetic patients.

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Section: Discussionsupporting

confidence: 92%

“…3 . These differences confirm how important it is for each laboratory involved in an AER study (1,5,12,22,25,26) to have their own normal range calculated on a proper group of healthy controls. Data from our 122 healthy subjects confirm that the distribution of urinary albumin excretion is not Gaussian (23,24,(26)(27)(28).…”

Section: Discussionmentioning

confidence: 65%