The interrelationship of blue and common naevi

Abstract

Extracts prepared from a halophilic bacterium contained a reduced nicotinamide adenine dinucleotide (NADH(2)) oxidase active at high solute concentrations. The cation requirement was nonspecific, since KCl, RbCl, and CsCl replaced NaCl with little or no loss of activity, and NH(4)Cl was only partially effective. Only LiCl failed to replace NaCl. No specific chloride requirement was observed although not all anions replaced chloride. Bromide, nitrate, and iodide were essentially ineffective, whereas acetate, formate, citrate, and sulfate proved suitable. The presence of sulfate affected the ability of a cation to satisfy the solute requirement. Sulfate enhanced the rate of NADH(2) oxidation when compared with the rate observed in the presence of chloride. Cations which were inactive as chlorides (LiCl and MgCl(2) at high concentrations) satisfied the cation requirement when added as sulfate salts. Although magnesium satisfied the cation requirement, a concentration effect, as well as an anion effect, was observed. In the presence of MgCl(2), little NADH(2) oxidation was observed at concentrations greater than 1 m. At lower concentrations, the rate of oxidation increased, reaching a maximal value at 0.1 m and remaining constant up to a concentration of 0.05 m MgCl(2). Magnesium acetate and MgSO(4) also replaced NaCl, and the maximal rate of oxidation occurred at 0.05 m with respect to magnesium. There was no change in the rate of oxidation at high magnesium acetate concentrations, whereas the rate of NADH(2) oxidation increased at higher concentrations of MgSO(4).

Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects

“…These tumors originate from melanocytes that are not epithelium related (blue nevi are thought to be derived from a small pool of melanocytes located in the dermis that have not reached the epidermis during embryogenesis (82) ). In contrast, common melanocytic nevi and cutaneous melanomas are derived from intra-epidermally located melanocytes (92).…”

Combined naevus: a benign lesion frequently misdiagnosed both clinically and pathologically as melanoma

“…Although the definition of combined naevus and typical histological features have been documented in a number of previous reports and dermatopathology texts, [1][2][3][4][6][7][8][9][10][11][15][16][17][18][19][20][21][22][23][24][25] such lesions are frequently seen in our consultation practice and are commonly misdiagnosed as melanoma by the referring clinician and/or pathologist. In view of this problem, we considered it useful to review and document our experience of these lesions.…”

Morphologic Changes of Acquired Melanocytic Nevi With Eccentric Foci of Hyperpigmentation (“Bolognia Sign”) Assessed by Dermoscopy

“…3 Other differential diagnoses of acquired melanocytic nevi with eccentric foci of hyperpigmentation include combined nevi. [8][9][10] The combined nevus originally referred to the occurrence of a common melanocytic nevus within a blue nevus. 8 The term combined nevi was coined in 1977 by Gartmann and Muller 9 to describe nevi characterized by the presence of 2 or more of the following types of nevi: common nevi, blue nevi, cellular blue nevi, and Spitz nevi.…”

“…[8][9][10] The combined nevus originally referred to the occurrence of a common melanocytic nevus within a blue nevus. 8 The term combined nevi was coined in 1977 by Gartmann and Muller 9 to describe nevi characterized by the presence of 2 or more of the following types of nevi: common nevi, blue nevi, cellular blue nevi, and Spitz nevi. According to some authors, any kind of melanocytic nevus (common acquired nevus, congenital nevus, or a Clark nevus) may be combined with other melanocytic nevi or with a blue or a Spitz nevus.…”