The interrelationship between non-motor symptoms in Atypical Parkinsonism

Lee, Chan Nyoung; Kim, Minjik; Lee, Hye Mi; Jang, Jin-Wook; Lee, Seon Min; Kwon, Do Young; Park, Kun Woo; Koh, Seong Beom

doi:10.1016/j.jns.2013.01.034

Cited by 23 publications

(23 citation statements)

References 26 publications

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“…In our study, using the PDQ-8, NMSS scores were more strongly associated with a worse QOL than UPDRS part III scores. This finding is consistent with studies in patients with both PD and Atypical Parkinsonism who had their QOL affected by NMSS scores more strongly than by the UPDRS part III scores [4,5]. Even considering these differences it is clear non-motor symptoms are capable of greatly affecting QOL.…”

Section: Discussionsupporting

confidence: 89%

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Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

et al. 2015

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Parkinson's disease (PD) is a multisystem disorder, and besides the classical motor symptoms it is now known that patients also suffer from a variety of non-motor symptoms that adversely affect quality of life (QOL). Since data on Hispanic populations on this issue are scarce, our aim was to study the association of non-motor symptoms and QOL in patients with PD. This study is a cross-sectional observational study involving patients with PD using the following instruments: Quality of Life Questionnaire (PDQ-8), Unified Parkinson's Disease Rating Scale part III (UPDRS part III), and Non-Motor Symptom Scale (NMSS). We included 52 patients, with a median age of 64 years. Sleep/fatigue and mood/cognitive domains were the most common non-motor symptoms. Only sleep/fatigue, mood/cognition and gastrointestinal domains were associated with worse PDQ-8 scores. After adjusting for confounding variables, NMSS scores were significantly associated with a high PDQ-8 score. Higher NMSS scores were associated with and predicted higher PDQ-8 scores. The focus of management in PD should shift to a comprehensive strategy that incorporates care of non-motor symptoms and improves QOL.

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Section: Discussionsupporting

confidence: 89%

“…The emphasis of treatment has also shifted from ameliorating motor symptoms to a more comprehensive approach that includes these factors [2,3]. In recent studies, non-motor symptoms have been shown to be most strongly associated with the patient's quality of life (QOL) [4,5].…”

Section: Introductionmentioning

confidence: 99%

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

et al. 2015

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“…The scores of Korean version of 39-item Parkinson’s disease questionnaire (PDQ-39), instrument for evaluating healthrelated quality of life (HrQoL) in PD patients, demonstrated significant relationships with NMSS scores [ 50 ]. The NMSS scores also significantly correlated with PDQ-39 scores in patients with MSA and PSP [ 51 ]. NMS progression contributes importantly to HrQoL decline [ 52 ] with a growing emphasis on the importance of HrQoL when managing PD patients.…”

Section: Nms and Quality Of Lifementioning

confidence: 99%

Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease

Lee

Koh²

2015

JMD

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125

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Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.

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“…These symptoms are described as nonmotor symptoms (NMS), which has been widely reported in patients with PD [ 8 ]. NMS were also reported to affect the HRQoL of patients with PSP [ 9 , 10 ], indicating that more attention should be paid to the management of these symptoms in PSP.…”

Section: Introductionmentioning

confidence: 99%

“…The PRIAMO study [ 9 ] found that the most frequent NMS in PSP are gastrointestinal symptoms (80%) and fatigue (80%) by conducting the clusters (gastrointestinal symptoms, pain, urinary symptoms, cardiovascular autonomic symptoms, sleep disorders, fatigue, apathy, attention, skin disorders, psychiatric symptoms, respiratory symptoms, and other symptoms) to evaluate the frequency of NMS. However, another study [ 10 ] found that the most frequent NMS in patients with PSP is attention/memory problem by applying the Nonmotor Symptoms Scale (NMSS) to assess the frequency of NMS.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy

Song

Wei

et al. 2016

Parkinson's Disease

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Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson's disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of “sleep/fatigue,” “mood/apathy,” “attention/memory,” “gastrointestinal,” “sexual dysfunction,” and “miscellaneous” domains in PSP group were significantly higher than those in HC group (P < 0.05). The frequency of “mood/apathy,” “attention/memory,” and “sexual dysfunction” domains and the severity of “attention/memory” and “gastrointestinal” domains in PSP group were significantly higher than those in PD group (P < 0.05). The “attention/memory” domain in PSP had a significant but weak-to-moderate correlation with age (R = 0.387, P = 0.046) and onset age (R = 0.406, P = 0.036). Conclusions. NMS are common in PSP patients. Patients with PSP seem to be subjected to more frequent and severe specific NMS compared to healthy aging subjects and PD patients. Older PSP patients and late-onset patients are likely to be subjected to cognitive decline.

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The interrelationship between non-motor symptoms in Atypical Parkinsonism

Cited by 23 publications

References 26 publications

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease

Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy

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