The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome

Milovanović, Tamara; Pantic, Ivana; Dragašević, Sanja; Lugonja, Sofija; Dumić, Igor; Rajilić‐Stojanović, Mirjana

doi:10.15403/jgld-3308

Cited by 19 publications

(20 citation statements)

References 75 publications

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“…It has been established that NAFLD is strongly associated with other metabolic comorbidities, including obesity, type 2 diabetes, dyslipidemia, cardiovascular disease, colonic diverticulosis, and neurodegenerative conditions [ 1 , 4 , 5 , 6 , 7 , 14 , 91 ]. Hepatic steatosis, which refers to a pathological state of the liver characterized by an accumulation of lipid content at over ~5% of the total organ weight, is closely associated with insulin resistance in multiple organs, as supported by several studies demonstrating impaired insulin action in both lean and non-diabetic obese individuals [ 14 , 92 , 93 , 94 ].…”

Section: Hepatokines and Nafldmentioning

confidence: 99%

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

2021

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The liver plays a key role in maintaining energy homeostasis by sensing and responding to changes in nutrient status under various metabolic conditions. Recently highlighted as a major endocrine organ, the contribution of the liver to systemic glucose and lipid metabolism is primarily attributed to signaling crosstalk between multiple organs via hepatic hormones, cytokines, and hepatokines. Hepatokines are hormone-like proteins secreted by hepatocytes, and a number of these have been associated with extra-hepatic metabolic regulation. Mounting evidence has revealed that the secretory profiles of hepatokines are significantly altered in non-alcoholic fatty liver disease (NAFLD), the most common hepatic manifestation, which frequently precedes other metabolic disorders, including insulin resistance and type 2 diabetes. Therefore, deciphering the mechanism of hepatokine-mediated inter-organ communication is essential for understanding the complex metabolic network between tissues, as well as for the identification of novel diagnostic and/or therapeutic targets in metabolic disease. In this review, we describe the hepatokine-driven inter-organ crosstalk in the context of liver pathophysiology, with a particular focus on NAFLD progression. Moreover, we summarize key hepatokines and their molecular mechanisms of metabolic control in non-hepatic tissues, discussing their potential as novel biomarkers and therapeutic targets in the treatment of metabolic diseases.

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Section: Hepatokines and Nafldmentioning

confidence: 99%

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

2021

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“…Recent studies that have looked at obesity and associated diseases have shown a direct relationship between visceral fat, non-alcoholic fatty liver disease, and diverticulosis. The relationship between the intestinal microbiome and the metabolic syndrome has been followed since 2013 [ 13 ], but dysbiosis and non-alcoholic fatty liver disease and diverticulosis appear in the most recent studies [ 14 ]. It seems that the disease of the fatty liver, visceral fat, and diverticulosis is the consequence of a marked dysbiosis, present in the metabolic syndrome [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Periodontal Bacteria with Chronic Inflammation Present in Patients with Metabolic Syndrome

Ghitea

2021

Biomedicines

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Metabolic syndrome (MS) is correlated with many chronic diseases, and so far is moderately followed and treated. The present study follows a correlation of the presence of pathogens (Fusobacterium nucleatum, Bacteroides forsythus, and others) in the gingival crevicular fluid and MS. (1) An important role in the fight against MS is to reduce fat mass, inflammatory mediators, and prevent cytokine-associated diseases. (2) A group of 111 people with MS was studied, divided into 3 groups. The control group (CG) received no treatment for either periodontitis or MS. The diet therapy group (DG) followed a clinical diet therapy specific to MS, and the diet therapy and sports group (DSG) in addition to diet therapy introduced regular physical activity; (3) A statistically significant worsening of periodontopathogens was observed correlated with the advancement of MS (increase in fat mass, visceral fat, and ECW/TBW ratio) in the CG group. In the case of DG and DSG groups, an improvement of the parameters was observed, including periodontal diseases. Therefore, anti-inflammatory diet therapy contributes to the reduction of gingival inflammation and thus contributes to the reduction of the development of pathogenic bacteria in the gingival, responsible for the development of periodontal disease and directly by other chronic diseases.

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“…Furthermore, it has recently suggested that NAFLD is a systemic disease which plays a critical role in metabolic syndrome; accordingly, the concept metabolic-dysfunction-associated fatty liver disease (MAFLD) has been proposed [ 5 ]. Excessive visceral adiposity in MAFLD, leading to a pro-inflammatory state, is an important risk factor for obesity-related complications such as colonic diverticulosis, which has the bi-directional relationship between metabolic syndrome or NAFLD [ 6 ]. NAFLD is a common liver disease characterized by fat accumulation in the liver in those individuals who do not drink heavily (>210 g in males and >150 g in females per week) [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects

Kim

Cho

Kim

et al. 2021

JCM

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The triglyceride glucose (TyG) index has been suggested as a marker for insulin resistance; however, few studies have investigated the clinical implications of markers that combine obesity markers with the TyG index. This study aimed to investigate the associations between non-alcoholic fatty liver disease (NAFLD) and TyG-related markers in healthy subjects in Korea. We enrolled 21,001 asymptomatic participants who underwent hepatic ultrasonography. The homeostasis model assessment of insulin resistance (HOMA-IR), TyG index, TyG-body mass index, and TyG-waist circumference (WC) were subsequently analyzed. NAFLD was diagnosed using hepatic ultrasonography. A multiple logistic regression analysis was performed to evaluate the associations between the quartiles of each parameter and the risk of NAFLD. The increase in the NAFLD risk was most evident when the TyG-WC quartiles were applied; the multivariate-adjusted odds ratios for NAFLD were 4.72 (3.65–6.10), 13.28 (10.23–17.24), and 41.57 (31.66–54.59) in the 2nd, 3rd, and 4th TyG-WC quartiles, respectively, when compared with the lowest quartile. The predictability of the TyG-WC for NAFLD was better than that of the HOMA-IR using the area under the curve. The TyG-WC index was superior to the HOMA-IR for identifying NAFLD in healthy Korean adults, especially in the non-obese population.

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The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome

Cited by 19 publications

References 75 publications

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

Correlation of Periodontal Bacteria with Chronic Inflammation Present in Patients with Metabolic Syndrome

Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects

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