The interplay of interleukin-17A and breast cancer tumor microenvironment as a novel immunotherapeutic approach to increase tumor immunogenicity

Moaaz, Mai; Lotfy, Hassan; Motawea, Mohamed A; Fadali, Gaylan

doi:10.1016/j.imbio.2021.152068

Cited by 8 publications

(2 citation statements)

References 50 publications

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“…A current study by Sparano et al demonstrated that a considerably increased risk of distant recurrence is linked to higher levels of the cytokine IL-6 at diagnosis in HER2-patients [138]. Aggressive BC is also linked to the presence of high amounts of IL-17A in the BC microenvironment [147,148].…”

Section: Cytokine Expression In the Breast Cancer Microenvironmentmentioning

confidence: 75%

Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

Kotsifaki,

Alevizopoulos,

Dimopoulou

et al. 2023

IJMS

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Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores the emerging frontiers of research focused on deciphering the intricate interplay between BC cells and the immune microenvironment. Understanding the role of the immune system in BC is critical as it holds promise for novel therapeutic approaches and precision medicine strategies. This review delves into the current literature regarding the immune microenvironment’s contribution to BC initiation, progression, and metastasis. It examines the complex mechanisms by which BC cells interact with various immune cell populations, including tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). Furthermore, this review highlights the impact of immune-related factors, such as cytokines and immune checkpoint molecules. Additionally, this comprehensive analysis sheds light on the potential biomarkers associated with the immune response in BC, enabling early diagnosis and prognostic assessment. The therapeutic implications of targeting the immune microenvironment are also explored, encompassing immunotherapeutic strategies and combination therapies to enhance treatment efficacy. The significance of this review lies in its potential to pave the way for novel therapeutic interventions, providing clinicians and researchers with essential knowledge to design targeted and personalized treatment regimens for BC patients.

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Section: Cytokine Expression In the Breast Cancer Microenvironmentmentioning

confidence: 75%

Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

Kotsifaki,

Alevizopoulos,

Dimopoulou

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, there is a paucity of information concerning the relationship of MDSC in Egyptian patients with BC [ 15 , 16 ], hence, we aimed to determine the frequency of different MDSC subsets in a cohort of female patients with BC compared to subjects with benign breast lesions as well as healthy controls. We also aimed to investigate the potential association of MDSC and their subsets with tumor size, distinct tumor histopathology, hormonal markers, and intake of neoadjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Analysis of Circulating Myeloid Derived Suppressor Cells and Their Subpopulations in Egyptian Females with Breast Cancer: A Single-Centre Case-Control Study

Saed,

Abbas,

El Ansary

et al. 2024

Asian Pac J Cancer Prev

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Background: Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with suppressive function that has been thoroughly documented in the setting of cancer. Our purpose was to evaluate levels of MDSC and their subsets in a cohort of Egyptian patients with breast cancer. Methods: Evaluation of peripheral blood total MDSC and its subset was done using multicolor flowcytometry in 30 malignant, 10 benign breast tumor patients and 10 healthy control females. Results: BC patients had higher total MDSC levels compared to controls (p= 0.01) particularly the Monocytic MDSC (M-MDSC) and abnormal MDSC subsets (p = 0.001 and p <0.001, respectively). A tumor size > 2 cm exhibited significantly higher granulocytic MDSCs (G-MDSCs) compared to tumor size < 2 cm (p= 0.02) whereas abnormal MDSCs were significantly higher in patients with a tumor size < 2 cm (p = 0.037). Conclusion: MDSC and its subsets can be used as a prognostic marker of tumor size as well as a potential targets for treatment in breast cancer patients.

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Role of low‐density cholesterol and Interleukin‐17 interaction in breast cancer pathogenesis and treatment

Liu,

Yang,

Wang

et al. 2024

Cell Biology International

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Breast cancer (BC) has become the most prevalent cancer worldwide, and further research is being conducted to deepen our understanding of its pathogenesis and treatment. Lipid metabolism disorder is a significant alteration in cancer cells, and the investigation into the role of Interleukin‐17 (IL‐17) in malignant tumors has emerged as a research focus in recent years. Thus, exploring changes in lipid metabolism and inflammatory factors in BC cells is crucial in identifying potential therapeutic targets. This article summarizes the progress made in the research on the main low‐density cholesterol (LDL) transporter and IL‐17 in lipid metabolism, and their potential involvement in the development of BC. The article aims to establish a theoretical foundation for the development of BC‐related therapies.

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The interplay of interleukin-17A and breast cancer tumor microenvironment as a novel immunotherapeutic approach to increase tumor immunogenicity

Cited by 8 publications

References 50 publications

Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

Phenotypic Analysis of Circulating Myeloid Derived Suppressor Cells and Their Subpopulations in Egyptian Females with Breast Cancer: A Single-Centre Case-Control Study

Role of low‐density cholesterol and Interleukin‐17 interaction in breast cancer pathogenesis and treatment

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