“…There is an ongoing effort to computationally and theoretically comprehend molecular structure, function, and properties of the chromatin ( D. Bascom and Schlick, 2018 ; Korolev et al., 2016 ; Laghmach et al., 2021 , 2020 ; Moller and de Pablo, 2020 ; Ozer et al., 2015 ). A number of simulation studies demonstrated that high concentrations of multivalent DNA-binding particles, representing generic transcription factors or epigenetic effectors, drive chromatin condensation, and phase separation ( Barbieri et al., 2012 ; Brackley et al., 2016 ; Jost et al., 2014 ; MacPherson et al., 2018 ; Michieletto et al., 2017a ; Nuebler et al., 2018 ).…”