The interplay of calponin, wnt signaling, and cytoskeleton protein governs transgenerational phenotypic abnormalities in drosophila exposed to zinc oxide nanoparticles

Anand, Avnika Singh; Verma, Kalyani; Amitabh,; Prasad, Dipti; Kohli, Ekta

doi:10.1016/j.cbi.2022.110284

Cited by 1 publication

(1 citation statement)

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“…In the highest concentrations evaluated (2.0 and 4.0 mg/mL), we observed low daily pupal formation (Figure ), high larval mortality rate, and low pupal formation (Figure ) for the exposure of animals to all NCs. It is already established that ZnO nanoparticles (NPs) are toxic to Drosophila and can induce the increased production of reactive oxygen species (ROS), resulting in oxidative stress and genotoxicity. − The high generation of ROS may be the cause of both the delay in postembryonic development and the high larval lethality after exposure to ZnO and ZnO:0.5Au [51,53,54]. ZnO NPs cause toxicity because they induce the generation of excess ROS and disrupt the flow of Ca 2+ , leading to cellular distress, which consequently induces a series of cellular damage, such as changes in Nrf2 signaling pathways, reduction of antioxidant proteins such as glutathione (GSH), redox imbalance, and mitochondrial dysfunction, which in the end lead to cell death. , …”

Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

Tuning Biocompatibility and Bactericidal Efficacy as a Function of Doping of Gold in ZnO Nanocrystals

Oliveira,

Silva,

Floresta

et al. 2024

ACS Omega

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Doping nanoparticles represents a strategy for modulating the energy levels and surface states of nanocrystals (NCs), thereby enhancing their efficiency and mitigating toxicity. Thus, we herein focus on the successful synthesis of pure and gold (Au)-doped zinc oxide (ZnO) nanocrystals (NCs), investigating their physical−chemical properties and evaluating their applicability and toxicity through in vitro and in vivo assessments. The optical, structural, and photocatalytic characteristics of these NCs were scrutinized by using optical absorption (OA), X-ray diffraction (XRD), and methylene blue degradation, respectively. The formation and doping of the NCs were corroborated by the XRD and OA results. While the introduction of Au as a dopant did induce changes in the phase and size of ZnO, a high concentration of Au ions in ZnO led to a reduction in their photocatalytic activity. This demonstrated a restricted antibacterial efficacy against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Remarkably, Au-doped counterparts exhibited enhanced biocompatibility in comparison to ZnO, as evidenced in both in vitro (murine macrophage cells) and in vivo (Drosophila melanogaster) studies. Furthermore, confocal microscopy images showed a high luminescence of Au-doped ZnO NCs in vivo. Thus, this study underscores the potential of Au doping of ZnO NCs as a promising technique to enhance material properties and increase biocompatibility.

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