The interplay between the microbiota and opioid in the treatment of neuropathic pain
Zexiong Gong,
Qingsheng Xue,
Yan Luo
et al.
Abstract:Neuropathic pain (NP) is characterized by its complex and multifactorial nature and limited responses to opioid therapy; NP is associated with risks of drug resistance, addiction, difficulty in treatment cessation, and psychological disorders. Emerging research on gut microbiota and their metabolites has demonstrated their effectiveness in alleviating NP and augmenting opioid-based pain management, concurrently mitigating the adverse effects of opioids. This review addresses the following key points: (1) the c… Show more
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