The Interplay between the Host Microbiome and Pathogenic Viral Infections

González, Rubén; Elena, Santiago F.

doi:10.1128/mbio.02496-21

Cited by 19 publications

(19 citation statements)

References 132 publications

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“…Precedent research suggests that vector‐borne infectious diseases can affect the success rate of virus infection, symptoms, and infectivity by the vector's microbiome (Carlson et al . 2020; Gonzalez & Elena 2021; Hegde et al . 2015).…”

Section: Resultsmentioning

confidence: 99%

“…Precedent research suggests that vector-borne infectious diseases can affect the success rate of virus infection, symptoms, and infectivity by the vector's microbiome (Carlson et al 2020;Gonzalez & Elena 2021;Hegde et al 2015). However, there are no studies have been conducted to find out the trends in the infection rate, symptom difference, and contagiousness of diseases according to the microbiome of ticks, including H. longicornis until these days.…”

Section: Alpha and Beta Diversity Analysismentioning

confidence: 99%

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Characterization of Haemaphysalis longicornis microbiome collected from different regions of Korean peninsula

Sang

Park

Song

et al. 2022

Entomological Research

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Ticks are vectors that cause disease by transmitting bacteria, viruses, and protozoa to humans or animals. The Asian longhorned tick Haemaphysalis longicornis, a vector of medical and veterinary importance, is widely distributed in the Korean peninsula and can transmit various pathogens including Rickettsia spp., Borrelia spp., Francisella spp., Coxiella spp., and severe fever with thrombocytopenia syndrome virus (SFTS virus). Despite the abundance and importance, studies on the microbiome of H. longicornis in Korea are limiting. Here we first report the microbiome diversity of H. longicornis in terms of region, stage, and sex. H. longicornis used in this study were collected from 16 different regions. The V3-V4 region was amplified and sequenced by MiSeq platform. The microbial diversity analysis was performed using Qiime2. A total of 1,754,418 non-chimeric reads were obtained from a total of 46 samples, and an average of 126 operational taxonomic units (OTUs) and a total of 1,398 OTUs were identified. Our results were used for H. longicornis microbial community database construction for each region that enables to identify singularities in each region.

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Section: Resultsmentioning

confidence: 99%

Section: Alpha and Beta Diversity Analysismentioning

confidence: 99%

Characterization of Haemaphysalis longicornis microbiome collected from different regions of Korean peninsula

Sang

Park

Song

et al. 2022

Entomological Research

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“…Orally administered virus has access primarily to the digestive tract, where it has to overcome local immune defence mechanisms and potentially interfering host microbiota to establish an infection and before it can spread to other tissue. The host gut microbiota in particular, which itself is interlinked with host nutrition and other environmental factors, might play a substantial role in viral defence mechanisms in bees (Dosch et al, 2021) and deserves greater research attention (González & Elena, 2021). In contrast, viral injection directly into the haemocoel provides systemic access to host tissue as a consequence of the host's open circulatory system, facilitating viral spread to permissive cells, which might explain the higher infectivity achieved by this route of infection (Tehel et al, 2020; Wang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Experimental viral spillover can harmBombus terrestrisworkers under field conditions

Streicher

Tehel

Tragust

et al. 2022

Ecological Entomology

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1. Deformed wing virus (DWV), notorious for its virulence in the western honey bee (Apis mellifera) when vectored by the ectoparasitic mite Varroa destructor, is also widespread among wild bumble bee species, presumably through spillover from honey bees. Experimental studies on the virulence of DWV in Bombus spp. have provided equivocal results and have until now been confined to bumble bees under laboratory conditions.2. Here, we inoculated commercially reared Bombus terrestris workers with DWV-A through feeding or injection and introduced them into experimental colonies placed in the field, thus exposing them to the environment and associated stressors. We monitored the survival of inoculated worker bumble bees and quantified their viral load at 10 days post inoculation.3. Bombus terrestris workers injected with DWV-A supported high viral loads and exhibited significantly reduced median survival compared to controls. Bumble bees inoculated by feeding had low or zero detectable viral loads while their mortality did not differ from the control group. 4. Our results demonstrate that, although DWV-A is pathogenic for commercial B. terrestris, the risks for individual fitness from spillover of DWV-A during foraging on shared flowers appear limited.

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“…Despite the current proposed dengue prognostic parameters, including C-reactive protein polymorphism variants (Mukherjee & Tripathi, 2020), ferritin (Suresh et al, 2020), granulocytemacrophage colony-stimulating factor (GM-CSF) (Lee et al, 2019), interferon gamma-inducible protein-10 (IP-10) (Chen et al, 2006), and vascular injury biomarkers (Vuong et al, 2021), leaky gut-associated parameters and innate immunity determination are also interesting. Furthermore, very little is known about the physiologic consequences of leaky gut, blood bacteriome, and gut dysbiosis in dengue as host-microbiome during dengue infection which can be beneficial or harmful to the host (Gonzaĺez & Elena, 2021). Here, the prospective singlecenter analysis on patients with dengue infection was conducted to see if the biomarkers of gut translocation, bacteriomes, and innate responses could be used as the prognostic factors in dengue infection.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Blood Bacteriome, Gut Dysbiosis, and Progression to Severe Dengue Disease

Chancharoenthana

Kamolratanakul

Ariyanon

et al. 2022

Front. Cell. Infect. Microbiol.

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Despite a well-known association between gut barrier defect (leaky gut) and several diseases, data on translocation of pathogen molecules, including bacterial DNA (blood bacteriome), lipopolysaccharide (LPS), and serum (1→3)-β-D-glucan (BG), from the gut to the blood circulation (gut translocation) in dengue are still less studied. Perhaps, dengue infection might induce gut translocation of several pathogenic molecules that affect the disease severity. At the enrollment, there were 31 dengue cases in febrile and critical phases at 4.1 ± 0.3 days and 6.4 ± 1.1 days of illness, respectively, with the leaky gut as indicated by positive lactulose-to-mannitol excretion ratio. With blood bacteriome, the patients with critical phase (more severe dengue; n = 23) demonstrated more predominant abundance in Bacteroidetes and Escherichia spp. with the lower Bifidobacteria when compared with the healthy control (n = 5). Meanwhile, most of the blood bacteriome results in dengue with febrile stage (n = 8) were comparable to the control, except for the lower Bifidobacteria in dengue cases. Additionally, endotoxemia at the enrollment was demonstrated in five (62.5%) and 19 (82.6%) patients with febrile and critical phases, respectively, while serum BG was detectable in two (25%) and 20 (87%) patients with febrile and critical phases, respectively. There were higher peripheral blood non-classical monocytes and natural killer cells (NK cells) at the enrollment in patients with febrile phage than in the cases with critical stage. Then, non-classical monocytes (CD14-CD16+) and NK cells (CD56+CD16-) increased at 4 and 7 days of illness in the cases with critical and febrile stages, respectively, the elevation of LPS and/or BG in serum on day 7 was also associated with the increase in monocytes, NK cells, and cytotoxic T cells. In summary, enhanced Proteobacteria (pathogenic bacteria from blood bacteriomes) along with increased endotoxemia and serum BG (leaky gut syndrome) might be collaborated with the impaired microbial control (lower non-classical monocytes and NK cells) in the critical cases and causing more severe disease of dengue infection.

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The Interplay between the Host Microbiome and Pathogenic Viral Infections

Abstract: The microorganisms associated with an organism, the microbiome, have a strong and wide impact in their host biology. In particular, the microbiome modulates both the host defense responses and immunity, thus influencing the fate of infections by pathogens.

Cited by 19 publications

References 132 publications

Characterization of Haemaphysalis longicornis microbiome collected from different regions of Korean peninsula

Characterization of Haemaphysalis longicornis microbiome collected from different regions of Korean peninsula

Experimental viral spillover can harmBombus terrestrisworkers under field conditions

Abnormal Blood Bacteriome, Gut Dysbiosis, and Progression to Severe Dengue Disease

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