The interplay between neutrophils and microbiota in cancer

Smith, Carolyne K.; Trinchieri, Giorgio

doi:10.1002/jlb.4ri0418-151r

Cited by 12 publications

(11 citation statements)

References 226 publications

(506 reference statements)

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“…It is known that infection with microbe can directly induce neutrophil recruitment to tissue sites. 45 , 46 Therefore, the impaired lymphocytes in patients with COVID-19 may easily lead to an infection with microbe, further promoting the activation and recruitment of neutrophils in the blood of patients.…”

Section: Potential Mechanisms Of Sars-cov-2-induced Immunopathologymentioning

confidence: 99%

COVID-19: immunopathogenesis and Immunotherapeutics

Liu

et al. 2020

Sig Transduct Target Ther

639

577

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The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and severe multiple organ dysfunction. Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19.

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Section: Potential Mechanisms Of Sars-cov-2-induced Immunopathologymentioning

confidence: 99%

COVID-19: immunopathogenesis and Immunotherapeutics

Liu

et al. 2020

Sig Transduct Target Ther

639

577

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“…Neutrophils are an essential part of innate immune system 71, 72 and their participation in cancer development is increasingly realized 73, 74. The duality of effects of neutrophils in cancer is implicated on its ability to get polarized by different cytokines to anti-tumor (N1) and pro-tumor (N2) phenotypes 75.…”

Section: Induction Of Neutrophils By Il-35 In Cancermentioning

confidence: 99%

Interleukin-35 as an Emerging Player in Tumor Microenvironment

Xue¹,

Yan²,

Kan³

2019

J. Cancer

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IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. Search for anti-IL-35 therapies have exhibited limited success in animal models. Contrarily, few studies have denied the idea that IL-35 plays a role in cancer. The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.

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“…An important contributor of chronic mucosal inflammation is the microbiome [100][101][102][103][104][105][106][107][108][109][110]. Recent data show that oral microbial dysbiosis, with enrichment of Fusobacterium species, is associated with advanced oral cavity cancer stage; however, how this dysbiosis contributes to tumor progression remains an open question [111].…”

Section: The Microbiome As a Primer For Inflammation And Hpv Mediated...mentioning

confidence: 99%

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

McKeon

Gallant

Kim

et al. 2022

Cancers

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While the two primary risk factors for head and neck squamous cell carcinoma (HNSCC) are alcohol and tobacco, viruses account for an important and significant upward trend in HNSCC incidence. Human papillomavirus (HPV) is the causative agent for a subset of oropharyngeal squamous cell carcinoma (OPSCC)—a cancer that is impacting a rapidly growing group of typically middle-aged non-smoking white males. While HPV is a ubiquitously present (with about 1% of the population having high-risk oral HPV infection at any one time), less than 1% of those infected with high-risk strains develop OPSCC—suggesting that additional cofactors or coinfections may be required. Epstein–Barr virus (EBV) is a similarly ubiquitous virus that is strongly linked to nasopharyngeal carcinoma (NPC). Both of these viruses cause cellular transformation and chronic inflammation. While dysbiosis of the human microbiome has been associated with similar chronic inflammation and the pathogenesis of mucosal diseases (including OPSCC and NPC), a significant knowledge gap remains in understanding the role of bacterial-viral interactions in the initiation, development, and progression of head and neck cancers. In this review, we utilize the known associations of HPV with OPSCC and EBV with NPC to investigate these interactions. We thoroughly review the literature and highlight how perturbations of the pharyngeal microbiome may impact host-microbiome-tumor-viral interactions—leading to tumor growth.

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The interplay between neutrophils and microbiota in cancer

Cited by 12 publications

References 226 publications

COVID-19: immunopathogenesis and Immunotherapeutics

COVID-19: immunopathogenesis and Immunotherapeutics

Interleukin-35 as an Emerging Player in Tumor Microenvironment

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

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