The interplay between mitochondrial dysfunction and NLRP3 inflammasome in multiple sclerosis: Therapeutic implications and animal model studies

Shadab, Alireza; Abbasi-Kolli, Mohammad; Saharkhiz, Mansoore; Ahadi, Seyed Hamed; Shokouhi, Behrooz; Nahand, Javid Sadri

doi:10.1016/j.biopha.2024.116673

Cited by 2 publications

(1 citation statement)

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“…Programmed necrosis is characterized by the release of endolysates and DAMPs, which contribute to inflammation ( 120 ). In pyroptotic cells, inflammatory bodies such as the NLRP3 inflammasome can be observed ( 121 ). During pyroptosis, inflammatory caspases activate and cleave GSDMD, releasing its N-terminal fragment (GSDMD-N), which forms pores in bacterial membranes leading to their death without damaging the host cell ( 119 ).…”

Section: Ferroptosis and Other Forms Of Cell Deathmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Ferroptosis and Other Forms Of Cell Deathmentioning

confidence: 99%