The interplay between electrical and chemical synaptogenesis

Jabeen, Shaista; Thirumalai, Vatsala

doi:10.1152/jn.00398.2018

Cited by 30 publications

(29 citation statements)

References 131 publications

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“…Since the three layers do not share the same number of neurons (only 253 of the 279 neurons are connected by electrical gap junctions), a certain group of nodes are prone to remain desynchronized for certain combinations of g el , g ch and g wl . However, the strong biological interplay between synapse types is crucial to the understanding of the neuronal network as an entity [80,81]. Therefore, the connectome should be modeled as a multilayer network.…”

Section: Discussionmentioning

confidence: 99%

Synchronization Patterns in Modular Neuronal Networks: A Case Study of C. elegans

Pournaki

Merfort

Ruiz

et al. 2019

Front. Appl. Math. Stat.

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We investigate synchronization patterns and chimera-like states in the modular multilayer topology of the connectome of Caenorhabditis elegans. In the special case of a designed network with two layers, one with electrical intra-community links and one with chemical inter-community links, chimera-like states are known to exist. Aiming at a more biological approach based on the actual connectivity data, we consider a network consisting of two synaptic (electrical and chemical) and one extrasynaptic (wireless) layers. Analyzing the structure and properties of this layered network using Multilayer-Louvain community detection, we identify modules whose nodes are more strongly coupled with each other than with the rest of the network. Based on this topology, we study the dynamics of coupled Hindmarsh-Rose neurons. Emerging synchronization patterns are quantified using the pairwise Euclidean distances between the values of all oscillators, locally within each community and globally across the network. We find a tendency of the wireless coupling to moderate the average coherence of the system: for stronger wireless coupling, the levels of synchronization decrease both locally and globally, and chimera-like states are not favored. By introducing an alternative method to define meaningful communities based on the dynamical correlations of the nodes, we obtain a structure that is dominated by two large communities. This promotes the emergence of chimera-like states and allows to relate the dynamics of the corresponding neurons to biological neuronal functions such as motor activities.

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Section: Discussionmentioning

confidence: 99%

Synchronization Patterns in Modular Neuronal Networks: A Case Study of C. elegans

Pournaki

Merfort

Ruiz

et al. 2019

Front. Appl. Math. Stat.

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“…Synapses are divided into two different subfamilies. While the family of electrical synapses is especially important during the development of the nervous system, chemical synapses are the dominant type of synapses in the adult nervous system [13,14]. Chemical synapses are composed of a transmitter-releasing presynaptic element and a signal-receiving and -processing postsynaptic compartment.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain

Distler

Schumann

Kesseler

et al. 2020

Cells

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Genetic disruption of synaptic proteins results in a whole variety of human neuropsychiatric disorders including intellectual disability, schizophrenia or autism spectrum disorder (ASD). In a wide range of these so-called synaptopathies a sex bias in prevalence and clinical course has been reported. Using an unbiased proteomic approach, we analyzed the proteome at the interaction site of the pre- and postsynaptic compartment, in the prefrontal cortex, hippocampus, striatum and cerebellum of male and female adult C57BL/6J mice. We were able to reveal a specific repertoire of synaptic proteins in different brain areas as it has been implied before. Additionally, we found a region-specific set of novel synaptic proteins differentially expressed between male and female individuals including the strong ASD candidates DDX3X, KMT2C, MYH10 and SET. Being the first comprehensive analysis of brain region-specific synaptic proteomes from male and female mice, our study provides crucial information on sex-specific differences in the molecular anatomy of the synapse. Our efforts should serve as a neurobiological framework to better understand the influence of sex on synapse biology in both health and disease.

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“…Gap junction‐coupled neural circuits in the nematode worm, Caenorhabditis elegans , modulate mechanosensory processing, such that active input neurons facilitate the network and inactive inputs suppress the network through shunting (Rabinowitch, Chatzigeorgiou, & Schafer, ). Furthermore, electrical and chemical synapses, when expressed at shared sites of contact, can mutually regulate each other's formation and function (Jabeen & Thirumalai, ). Gap junctions between premotor interneurons and motor neurons can lead to amplified chemical transmission at mixed synapses and disrupting electrical synaptic function can inhibit chemical transmission (Liu, Chen, Mailler, & Wang, ).…”

Section: Discussionmentioning

confidence: 99%

Coupled sensory interneurons mediate escape neural circuit processing in an aquatic annelid worm, Lumbriculus variegatus

Lybrand

Martinez-Acosta

Zoran

2019

J of Comparative Neurology

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The interneurons associated with rapid escape circuits are adapted for fast pathway activation and rapid conduction. An essential aspect of fast activation is the processing of sensory information with limited delays. Although aquatic annelid worms have some of the fastest escape responses in nature, the sensory networks that mediate their escape behavior are not well defined. Here, we demonstrate that the escape circuit of the mud worm, Lumbriculus variegatus, is a segmentally arranged network of sensory interneurons electrically coupled to the central medial giant fiber (MGF), the command-like interneuron for head withdrawal. Electrical stimulation of the body wall evoked fast, short-duration spikelets in the MGF, which we suggest are the product of intermediate giant fiber activation coupled to MGF collateral dendrites. Since these contact sites have immunoreactivity with a glutamate receptor antibody, and the glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dion abolishes evoked MGF responses, we conclude that the afferent pathway for MGFmediated escape is glutamatergic. This electrically coupled sensory network may facilitate rapid escape activation by enhancing the amplitude of giant axon depolarization.

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The interplay between electrical and chemical synaptogenesis

Cited by 30 publications

References 131 publications

Synchronization Patterns in Modular Neuronal Networks: A Case Study of C. elegans

Synchronization Patterns in Modular Neuronal Networks: A Case Study of C. elegans

Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain

Coupled sensory interneurons mediate escape neural circuit processing in an aquatic annelid worm, Lumbriculus variegatus

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