The interplay between bone and vessels in pediatric CKD: lessons from a single-center study

Preka, Evgenia; Ranchin, Bruno; Doyon, Anke; Vierge, M.; Ginhoux, Tiphanie; Kassai, Behrouz; Bacchetta, Justine

doi:10.1007/s00467-018-3978-3

Cited by 14 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously showed in our Vitados cohort a signi cant proportion of calcium de ciency, the median (range) calcium intake in this cohort indeed being of 812 (132-1382) mg [22]. Using the same HR-pQCT technique in the 32 adolescent from Lyon included in the 4C study (median GFR of 33 mL/min per 1.73m 2 ), we already provided reassuring data concerning bone health in these children with moderate CKD, and, again tightly controlled mineral biomarkers (median PTH 1.2 ULN) [14].…”

Section: Discussionmentioning

confidence: 58%

Changes in High Resolution peripheral Quantitative Computed Tomography in adolescents undergoing a first kidney transplantation.

De Mul,

Leclerc,

Ginhoux

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose Mineral bone disorders associated to chronic kidney disease (CKD-MBD) frequently persist after kidney transplantation (Tx), being due to pre-existing CKD-MBD, immunosuppressive therapies and post-Tx hypophosphatemia. We aimed to evaluate bone biomarkers and microarchitecture at the time of and 6 months after Tx. Methods Here we present the single-center sub-group of patients included between 10 and 18 years of age from the prospective TRANSOS study (NCT02729142). Patients undergoing a first Tx were matched on a 1:2 basis on sex, puberty and age with healthy controls (HC) from the VITADOS cohort. Results are presented as median (Q1-Q3). Non-parametric tests were performed. Results At a median age of 15 (13-16) years, 19 patients (6 girls, 7 pre-emptive Tx, 7 steroid-sparing immunosuppressive strategies) underwent a first Tx, with PTH levels of 1.9 (1.4-2.9) the upper limit of normal (ULN). When comparing HC and patients at the time of Tx, we found significantly higher total and trabecular densities with High Resolution peripheral Quantitative Computed Tomography (HR-pQCT). Six months after Tx, patients displayed significantly impaired trabecular parameters at radius compared to baseline; results were not different at the weight-bearing tibia, neither cortical parameters at both sites. Six months after Tx, 6 (31%) patients displayed acidosis, 10 (53%) persistent hyperparathyroidism (always < 2 ULN) and 5 (26%) increased FGF23 levels; 11 (58%) received phosphate supplementation. Conclusion Data on bone health in adolescent receiving a first Tx seem reassuring, but radial trabecular bone microarchitecture impairment observed 6 months post-Tx may reflect subtle albeit present post-Tx CKD-MBD. NCT02729142- March 25 2016

show abstract

Section: Discussionmentioning

confidence: 58%

Changes in High Resolution peripheral Quantitative Computed Tomography in adolescents undergoing a first kidney transplantation.

De Mul,

Leclerc,

Ginhoux

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Preka et al. 32 demonstrated that trabecular thickness by high-resolution pQCT was positively associated with diastolic and mean arterial BP. The second study, by Ziolkowska et al.…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density and Vascular Calcification in Children and Young Adults With CKD 4 to 5 or on Dialysis

Lalayiannis

2023

Kidney International Reports

View full text Add to dashboard Cite

“…There is a paucity of studies examining bone and cardiovascular status in children and young adults with CKD. Preka et al demonstrated that trabecular thickness by high resolution-pQCT (HR-pQCT) was positively associated with diastolic and mean arterial BP [ 135 ]. Ziolkowska et al showed that cIMT correlated with lumbar spine BMD and total body DXA [ 136 ].…”

Section: Bone–vascular Link In Ckdmentioning

confidence: 99%

Chronic kidney disease mineral bone disorder in childhood and young adulthood: a ‘growing’ understanding

Lalayiannis,

Soeiro,

Moysés

et al. 2023

Pediatr Nephrol

View full text Add to dashboard Cite

Chronic kidney disease (CKD) mineral and bone disorder (MBD) comprises a triad of biochemical abnormalities (of calcium, phosphate, parathyroid hormone and vitamin D), bone abnormalities (turnover, mineralization and growth) and extra-skeletal calcification. Mineral dysregulation leads to bone demineralization causing bone pain and an increased fracture risk compared to healthy peers. Vascular calcification, with hydroxyapatite deposition in the vessel wall, is a part of the CKD-MBD spectrum and, in turn, leads to vascular stiffness, left ventricular hypertrophy and a very high cardiovascular mortality risk. While the growing bone requires calcium, excess calcium can deposit in the vessels, such that the intake of calcium, calcium- containing medications and high calcium dialysate need to be carefully regulated. Normal physiological bone mineralization continues into the third decade of life, many years beyond the rapid growth in childhood and adolescence, implying that skeletal calcium requirements are much higher in younger people compared to the elderly. Much of the research into the link between bone (de)mineralization and vascular calcification in CKD has been performed in older adults and these data must not be extrapolated to children or younger adults. In this article, we explore the physiological changes in bone turnover and mineralization in children and young adults, the pathophysiology of mineral bone disease in CKD and a potential link between bone demineralization and vascular calcification. Graphical abstract

show abstract

The interplay between bone and vessels in pediatric CKD: lessons from a single-center study

Cited by 14 publications

References 48 publications

Changes in High Resolution peripheral Quantitative Computed Tomography in adolescents undergoing a first kidney transplantation.

Changes in High Resolution peripheral Quantitative Computed Tomography in adolescents undergoing a first kidney transplantation.

Bone Mineral Density and Vascular Calcification in Children and Young Adults With CKD 4 to 5 or on Dialysis

Chronic kidney disease mineral bone disorder in childhood and young adulthood: a ‘growing’ understanding

Contact Info

Product

Resources

About