The Internet for Distribution

Frost, Raymond D.; Fox, Alexa K.; Daugherty, Terry M.

doi:10.4324/9781003247319-15

Cited by 1 publication

(1 citation statement)

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“…Hypoadiponectinemia was defined as serum adiponectin values below the fifth centile, hyperleptinemia and high leptin: adiponectin ratios were defined as serum leptin values or leptin: adiponectin ratios above the 95th centile specific for the population per sex. 17 Information on fasting plasma glucose (FPG) concentration was obtained using an enzymatic method (hexokinase method by colorimetry). Diabetes was defined as self-reported diabetes and/or use of a hypoglycemic agent and/or fasting blood glucose >7mmol/L and/or HBA1C > 48 mmol/mol or >6.5%.…”

Section: Methodsmentioning

confidence: 99%

Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study

Kusi-Mensah,

Hayfron-Benjamin,

Chetty

et al. 2023

Clin Med Insights Endocrinol Diabetes

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Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified. Objectives: To compare the serum levels of adiponectin and leptin among migrant, and non-migrant (urban and rural) populations of Ghanaian descent. Methods: Cross-sectional analysis of serum leptin and adiponectin in the multi-centre Research on Obesity and Diabetes among African Migrants (RODAM) study. Logistic-regression models were used to examine the association between these adipocyte-derived hormones after stratification (sex, geographic area) and adjustments for potential confounders. Results: A total of 2518 Ghanaians were included. Rural participants had the highest serum adiponectin and lowest leptin levels compared to Amsterdam and urban Ghanaians ( P < .001). In fully adjusted models, participants living in urban Ghana had significantly higher odds of hyperleptinemia compared to rural participants (women-odds ratio 2.88; 95% CI, 1.12-7.38, P = .028 and men 43.52, 95% CI, 4.84-391.25, P < .001). Urban Ghanaian men also had higher odds of elevated leptin: adiponectin ratio (6.29, 95% CI, 1.43-27.62, P = .015). The odds of hyperleptinemia were only higher in Amsterdam Ghanaian men (10.56; 95% CI, 1.11-100.85, P = .041), but not in women (0.85; 95% CI, 0.30-2.41, P = .759). There was no significant association between hypoadiponectinemia and geographical location in both sexes. Conclusion: Urbanization is associated with serum adiponectin and leptin levels after adjusting for confounding covariates in sub-Saharan Africans. These findings serve as a backdrop for further research on the role adipokines play in CMD epidemiology among Africans.

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Section: Methodsmentioning

confidence: 99%