The variable development of the zygoma, dictating its shape and size variations among ancestral groups, has important clinical implications and valuable anthropological and evolutionary inferences. The purpose of the study was to review the literature regarding the variations in the zygoma with ancestry. Ancestral variation in the zygoma reflects genetic variations because of genetic drift as well as natural selection and epigenetic changes to adapt to diet and climate variations with possible intensification by isolation. Prominence of the zygoma, zygomaxillary tuberosity, and malar tubercle have been associated with Eastern Asian populations in whom these features intensified. Prominence of the zygoma is also associated with groups from Eastern Europe and the rest of Asia. Diffusion of these traits occurred across the Behring Sea to the Arctic areas and to North and South America. The greatest zygomatic projections are exhibited in Arctic groups as an adaptation to extreme cold conditions, while Native South American groups also present with other features of facial robusticity. Groups from Australia, Malaysia, and Oceania show prominence of the zygoma to a certain extent, possibly because of archaic occupations by undifferentiated Southeast Asian populations. More recent interactions with Chinese groups might explain the prominent cheekbones noted in certain South African groups. Many deductions regarding evolutionary processes and diversifications of early groups have been made. Cognisance of these ancestral variations also have implications for forensic anthropological assessments as well as plastic and reconstructive surgery. More studies are needed to improve accuracy of forensic anthropological identification techniques. Anat Rec, 300:196-208, 2017. V C 2016 Wiley Periodicals, Inc.Key words: evolution; malar prominence; zygomaxillary tuberosity; malar tubercle; native AmericanThe variable prominence of the cheek, known as the zygoma, is largely attributable to the shape of the underlying zygomatic and maxillary bones (Enlow and Hans, 1996;Standring, 2008). The extent of the development of the zygoma and, therefore, its shape and size varies among ancestral groups and has important correlations with the morphology of other features of the face such as the orbit, nasal cavity, and the mandible. Ancestral variations have been extensively researched and are thought to reflect subsistence, adaptation to climate, isolation and/or to historic contacts among human groups. Many deductions regarding evolutionary processes and