The intermediary role of a steroid 8,14-dien-3β-ol system in ergosterol biosynthesis

Akhtar, Muhammad; Brooks, W. A.; Watkinson, I. A.

doi:10.1042/bj1150135

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Cited by 16 publications

References 7 publications

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The Biosynthesis of Ergosterol

Mercer

1984

Pestic. Sci.

116

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The present state of knowledge of ergosterol biosynthesis is reviewed briefly in order to provide a contextual framework for the following papers which deal with its inhibition, the compounds that cause this inhibition, and their mode of action. The paper concentrates upon the post‐squalene segment of the process as it occurs in fungi because the commercially important inhibitors of ergosterol biosynthesis are fungicides that block steps within that process.

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The Biosynthesis of Ergosterol

Mercer

1984

Pestic. Sci.

116

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Sterol Biosynthesis

Weete

1974

Fungal Lipid Biochemistry

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Biochemical and physiological effects of sterol alterations in yeast—A review

Parks

Smith

Crowley

1995

Lipids

129

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Considerable progress has been made in the selection and characterization of mutants that are defective in the synthesis of ergosterol in the yeast, Saccharomyces cerevisiae. Mutations in nearly every step of the yeast sterol biosynthetic pathway have been induced and selected. These mutants have been used to elucidate the sequential order of steps in sterol synthesis, to study the mode of action of antifungal agents and to determine the method of resistance of some pathogenic fungi, and to answer questions on the role of sterols in general cell biology. Physiological examination of ergosterol null mutants, lacking all biochemical activity attributed to the particular gene, supports a role for ergosterol in a number of critical functions in the organism. Among the physiological functions attributed to ergosterol are sparking and bulking requirements, involvement in amino acid and pyrimidine transport, resistance to antifungal agents and certain cations, and a requirement for respiratory activity. Those genetic null alleles discussed in this review are erg24, lacking the ability to reduce the delta 14 double bond; erg6, unable to methylate C-24; and erg3, defective in the C-5 desaturase. The different biochemical activities that are disrupted in the ergosterol mutants support a role for ergosterol in a number of critical functions in yeast.

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The intermediary role of a steroid 8,14-dien-3β-ol system in ergosterol biosynthesis

Cited by 16 publications

References 7 publications

The Biosynthesis of Ergosterol

The Biosynthesis of Ergosterol

Sterol Biosynthesis

Biochemical and physiological effects of sterol alterations in yeast—A review

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