The interleukin-8 (−251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma

Vairaktaris, Eleftherios; Yapijakis, Christos; Serefoglou, Zoe; Derka, Spyridoula; Vassiliou, Stavros; Nkenke, Emeka; Vylliotis, Antonis; Wiltfang, Jens; Avgoustidis, Dimitrios; Critselis, Elena; Neukam, Friedrich Wilhelm; Patsouris, Efstratios

doi:10.1016/j.ejso.2006.11.002

Cited by 77 publications

(75 citation statements)

References 19 publications

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“…22 Polymorphisms in the IL-10 gene are found to play important role in cancer progression. Studies showed that IL-10 −1082A/G SNP was associated with poor prognosis of head and neck cancer, 23 oral cancer, 24 oral squamous cell, 25 cutaneous malignant melanoma, 26 prostate cancer, 27,28 digestive cancer, 29 and cervical carcinoma. 30 IL-10 −819C/T SNP found to be associated with the risk of lung cancer, 31 urothelial bladder cancer, 32 and head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues

et al. 2017

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Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, −1082A/G, −819T/C and −592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non-inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. We enrolled 105 breast cancer tissue (72 non-inflammatory breast cancer and 33 inflammatory breast cancer) patients and we determined the three studied single nucleotide polymorphisms in all samples by polymerase chain reaction restriction fragment length polymorphism and investigated their association with the disease and with various prognostic factors. In addition, we assessed the expression of interleukin-10 gene by realtime quantitative reverse transcription polymerase chain reaction and the correlation between studied single nucleotide polymorphisms and interleukin-10 messenger RNA expression. We found co-dominant effect as the best inheritance model (in the three studied single nucleotide polymorphisms in non-inflammatory breast cancer and inflammatory breast cancer samples), and we didn't identify any association between single nucleotide polymorphisms genotypes and breast cancer prognostic factors. However, GCC haplotype was found highly associated with inflammatory breast cancer risk (p < 0.001, odds ratio = 43.05). Moreover, the expression of interleukin-10 messenger RNA was significantly higher (p < 0.001) by 5.28-fold and 8.95-fold than non-inflammatory breast cancer and healthy control, respectively, where GCC haplotype significantly increased interleukin-10 gene expression (r = 0.9, p < 0.001).

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Section: Introductionmentioning

confidence: 99%

Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues

et al. 2017

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“…The human IL10 gene, composed of five exons and four introns, is mapped to chromosome 119 between 1q31 and 1q32, which displays three common polymorphisms in the gene promoter region: -1082 A/G (rsl800896), -819 T/C (rsl800871), and -592C/A (rsl800872). It has been reported that these polymorphisms influence the transcription and secretion of IL10 [18] and are associated with susceptibility to a range of cancers, such as oral squamous cell carcinoma, breast cancer, and cutaneous malignant melanoma [19][20][21]. Within the past few years, several studies have investigated the association between polymorphism of IL-10-1082 A/G and NPC risk.…”

Section: Introductionmentioning

confidence: 99%

A pooled analysis of the IL-10-1082 A/G polymorphism and the nasopharyngeal carcinoma susceptibility

et al. 2014

Eur Arch Otorhinolaryngol

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It has been reported that IL-10-1082 A/G polymorphism might influence the transcription and secretion of IL10 and tumor development. While many studies have been conducted to investigate the association between IL-10-1082 A/G polymorphism and risk of nasopharyngeal carcinoma (NPC) in various populations, the results of these studies are still controversial. We aimed to explore this relationship through a cumulative meta-analysis. A search of the literature was performed using the Cochrane Library, PubMed, and EMBASE databases. The odds ratio (OR) and corresponding 95 % confidence interval (CI) were calculated to assess this possible association. Six studies were included in the study. The meta-analysis reveals a significant effect in the allelic model (G vs. A: OR 1.516, 95 % CI 1.077-2.133, P heterogeneity = 0.003), dominant model (AG + GG vs. AA: OR = 1.770, 95 % CI 1.415-2.212, P heterogeneity = 0.169), and co-dominant model (AG vs. AA: OR = 1.747, 95 % CI 1.377-2.216, P heterogeneity = 0.491). Similarly, in the stratified analyses, significant effects were reported in studies of Asian populations. Our meta-analysis results suggest that the IL-10-1082 A/G variant is associated with increased risk of NPC in Asian populations.

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“…Oral squamous cell carcinoma (OSCC) encompasses more than 90% of all oral malignancies (Neville and Day 2002;Vairaktaris et al 2006Vairaktaris et al , 2007aVairaktaris et al , b, c, 2008Yapijakis et al 2008). OSCC remains the eighth most common malignancy in the world, and is a notable cause of morbidity and mortality worldwide (Williams 2000;Massano et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Gene expression polymorphisms of interleukins-1β, -4, -6, -8, -10, and tumor necrosis factors-α, -β: regression analysis of their effect upon oral squamous cell carcinoma

Vairaktaris

Yapijakis

Serefoglou

et al. 2008

J Cancer Res Clin Oncol

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The interleukin-8 (−251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma

Cited by 77 publications

References 19 publications

Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues

Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues

A pooled analysis of the IL-10-1082 A/G polymorphism and the nasopharyngeal carcinoma susceptibility

Gene expression polymorphisms of interleukins-1β, -4, -6, -8, -10, and tumor necrosis factors-α, -β: regression analysis of their effect upon oral squamous cell carcinoma

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