The interictal dysphoric disorder: recognition, pathogenesis, and treatment of the major psychiatric disorder of epilepsy

Blumer, Dietrich; Montouris, Georgia; Davies, Keith G.

doi:10.1016/j.yebeh.2004.08.003

Cited by 160 publications

(117 citation statements)

References 17 publications

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“…Other notable symptoms include atypical pain, phases of euphoric/dysphoric affect, anxiety and phobic symptoms. Blumer et al (2004) described interictal dysphoric disorder of epilepsy, which presents with recurrent brief episodes of mild depressive symptoms. This disorder was initially thought to be specific to patients with epilepsy but recent studies show the presence of similar episodes in other neurological conditions (Mula 2008).…”

Section: Interictal Depressionmentioning

confidence: 99%

Epilepsy and neuropsychiatric comorbidities

Agrawal¹,

Govender²

2011

Adv. psychiatr. treat

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SummaryEpilepsy is a common neurological condition with wide-ranging neuropsychiatric manifestations. The relationship between epilepsy and psychiatry has been recognised for centuries. However, the wide range of neuropsychiatric comorbidities and their extent is only now beginning to be appreciated. The impact of these comorbidities on patients' help-seeking behaviour, seizure control and quality of life suggests that early detection and treatment are of paramount importance. Clinical issues in relation to accurate recognition and appropriate management of neuropsychiatric conditions in epilepsy are discussed.

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Section: Interictal Depressionmentioning

confidence: 99%

Epilepsy and neuropsychiatric comorbidities

Agrawal¹,

Govender²

2011

Adv. psychiatr. treat

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“…In 1984, Himmelhoch 8 described a "dysthymic interictal subictal state" in patients with a moderate chronic state of depression during seizure-free periods. In descri bing the same manifestation, Blumer 9 preferred the term "dysphoric" because this term would be the best translation of Kraepelin's initial idea, especially concerning the frequency and periodicity of the mood swings, irritability, and aggressive outbursts.…”

Section: Introductionmentioning

confidence: 99%

Interictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers

Nascimento

Oliva

Franco

et al. 2013

Arq. Neuro-Psiquiatr.

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ARTICLEInterictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers ABSTRACTPsychiatric disorders are frequent among patients with epilepsy. Data in the literature have shown a heterogeneous clinical presentation of psychiatric disorders in patients with epilepsy. Interictal dysphoric disorder could be a specific psychiatric comorbidity associated with epilepsy, primarily in patients treated in tertiary centers. Objective: The present study aimed to determine the prevalence of interictal dysphoric disorder among patients with epilepsy who were followed in two tertiary epilepsy services in Brazil. Method: Sixty-five patients with epilepsy completed the Portuguese version of the Interictal Dysphoric Disorder Inventory. Results: Thirty-three (50.7%) patients fulfilled the diagnostic criteria for interictal dysphoric disorder, although all participants answered positively to having at least one key symptom. Conclusion: The high rate of patients with epilepsy who fulfilled the diagnosis of interictal dysphoric disorder confirms an association between epilepsy and psychiatric disorders. However, there is clearly a need to improve diagnostic tools to allow better differentiation between interictal dysphoric disorder and other psychiatric disorders.Keywords: epilepsy, interictal dysphoric disorder, psychiatric disorders. RESUMOTranstornos psiquiátricos são frequentes entre pacientes com epilepsia. Estudos evidenciam apresentações clínicas heterogêneas neste grupo. O transtorno disfórico interictal pode um transtorno específico destes pacientes, particularmente naqueles acompanhados em centros terciários. Objetivo: Determinar a prevalência de transtorno disfórico interictal entre pacientes com epilepsia atendidos em dois serviços terciários de epilepsia do Brasil. Método: Sessenta e cinco pacientes foram convidados a responder a versão brasileira do Interictal Dysphoric Disorder Inventory adaptado e validado para o Português. Resultados: Trinta e três pacientes (50,7%) preencheram critérios para transtorno disfórico interictal, embora todos os entrevistados tenham afirmado que são acometidos por ao menos um dos sintomas-chave. Conclusão: A alta prevalência de transtorno disfórico interictal em pacientes com epilepsia pode ser um indício da associação entre epilepsia e transtornos psiquiátricos. No entanto, é necessário melhorar a acurácia dos instrumentos de diagnóstico para poder diferenciar casos de transtorno disfórico interictal de outros transtornos psiquiátricos.Palavras-chave: epilepsia, transtorno disfórico interictal, transtornos psiquiátricos.

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“…Interestingly, the concept of IDD goes beyond the mood disorder per se, encompassing a spectrum of conditions with transient psychotic features or even prolonged psychotic states. In other words, Blumer suggests that interictal psychoses of epilepsy represent severe forms of IDD with prominent psychotic features [15,27].…”

Section: The Non-conforming Features Of Mood Disorders In Epilepsy Anmentioning

confidence: 99%

“…However, the symptom cluster described in patients with IDD and epilepsy is quite peculiar and is rarely reported in psychiatric practice even in rapid cycling bipolar disorders or cyclothymia [28]. Probably for this reason, Blumer stated that IDD is unique for epilepsy [27].…”

Section: The Non-conforming Features Of Mood Disorders In Epilepsy Anmentioning

confidence: 99%

The interictal dysphoric disorder of epilepsy: Legend or reality?

Mula

2016

Epilepsy & Behavior

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For a long time, the relationships between epilepsy and mood disorders captured the attention of clinicians and neuroscientists. The existence of a peculiar clinical presentation for mood disorders in epilepsy has been matter of debate since the early reports of Kraepelin and Bleuler. The interictal dysphoric disorder (IDD) represents the modern reinterpretation of such early observations. This paper reviews current research on this topic discussing clinical implications, phenomenological observations and directions for future research.

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The interictal dysphoric disorder: recognition, pathogenesis, and treatment of the major psychiatric disorder of epilepsy

Cited by 160 publications

References 17 publications

Epilepsy and neuropsychiatric comorbidities

Epilepsy and neuropsychiatric comorbidities

Interictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers

The interictal dysphoric disorder of epilepsy: Legend or reality?

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