The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection

Wussow, Peter von; Jakschies, D; Block, Berthold; Tschechne, B.; Schedel, I.; Horisberger, Michel A.; Hochkeppel, Heinz‐Kurt; Deicher, H.

doi:10.1097/00002030-199002000-00004

Cited by 40 publications

(28 citation statements)

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“…Importantly, it was shown in a group of HIV-infected patients that the level of PBMC-associated Mx protein correlated with the clinical stage of the patient (94). Patients with more advanced disease had higher levels of Mx (93). This is consistent with our data showing persistently increased Mx PBMC mRNA levels in the naïve and vaccinated-unprotected animals p.c.…”

Section: Discussionsupporting

confidence: 91%

Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses

Abel

Compton

Rourke

et al. 2003

J Virol

101

155

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Section: Discussionsupporting

confidence: 91%

Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses

Abel

Compton

Rourke

et al. 2003

J Virol

101

155

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“…Consistent with these results, it was shown in a group of HIV-infected patients that only a minority of the patients had elevated IFN-␣ plasma levels, whereas almost all of the patients had increased Mx protein levels in their PBMC (108). In addition, the level of PBMC-associated Mx protein correlated with the disease stage of the patient (20,108). As we have shown for the monkeys in the present study, the rapid HIV progressors had higher Mx levels than slow progressors (108).…”

Section: Discussionsupporting

confidence: 81%

“…In addition, the level of PBMC-associated Mx protein correlated with the disease stage of the patient (20,108). As we have shown for the monkeys in the present study, the rapid HIV progressors had higher Mx levels than slow progressors (108).…”

Section: Discussionsupporting

confidence: 81%

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

Abel

Alegria-Hartman

Rothaeusler

et al. 2002

J Virol

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To define the role of alpha/beta interferons (IFN-α/β) in simian immunodeficiency virus (SIV) infection, IFN-α and IFN-β mRNA levels and mRNA levels of Mx, an antiviral effector molecule, were determined in lymphoid tissues of rhesus macaques infected with pathogenic SIV. IFN-α/β responses were induced during the acute phase and persisted in various lymphoid tissues throughout the chronic phase of infection. IFN-α/β responses were most consistent in tissues with high viral RNA levels; thus, IFN-α/β responses were not generally associated with effective control of SIV replication. IFN-α/β responses were differentially regulated in different lymphoid tissues and at different stages of infection. The most consistent IFN-α/β responses in acute and chronic SIV infection were observed in peripheral lymph nodes. In the spleen, only a transient increase in IFN-α/β mRNA levels during acute SIV infection was observed. Further, IFN-α and IFN-β mRNA levels showed a tissue-specific expression pattern during the chronic, but not the acute, phase of infection. In the acute phase of infection, SIV RNA levels in lymphoid tissues of rhesus macaques correlated with mRNA levels of both IFN-α and IFN-β, whereas during chronic SIV infection only increased IFN-α mRNA levels correlated with the level of virus replication in the same tissues. In lymphoid tissues of all SIV-infected monkeys, higher viral RNA levels were associated with increased Mx mRNA levels. We found no evidence that monkeys with increased Mx mRNA levels in lymphoid tissues had enhanced control of virus replication. In fact, Mx mRNA levels were associated with high viral RNA levels in lymphoid tissues of chronically infected animals.

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“…Transfected cells (11,12,18) and transgenic mice (13) expressing MxA acquire a high degree of antiviral resistance, demonstrating that MxA is a powerful antiviral agent. In humans, synthesis of MxA is induced during acute viral infections and may thus protect humans from severe disease (20,21). However, the mechanisms by which MxA is able to inhibit such a diverse group of viruses is far from being understood.…”

mentioning

confidence: 99%

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids

Kochs

Haller

1999

Proc. Natl. Acad. Sci. U.S.A.

181

125

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Interferon-induced human MxA protein belongs to the dynamin superfamily of large GTPases. It exhibits antiviral activity against a variety of RNA viruses, including Thogoto virus, an inf luenza virus-like orthomyxovirus transmitted by ticks. Here, we report that MxA blocks the transport of Thogoto virus nucleocapsids into the nucleus, thereby preventing transcription of the viral genome. This interaction can be abolished by a mAb that neutralizes the antiviral activity of MxA. Our results reveal an antiviral mechanism whereby an interferon-induced protein traps the incoming virus and interferes with proper transport of the viral genome to its ultimate target compartment within the infected cell.

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The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection

Cited by 40 publications

References 0 publications

Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses

Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids

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