The interfascicular nerve-grafting of median and ulnar nerves

Millesi, H.; Meissl, G.; Berger, A.

doi:10.1097/00006534-197302000-00061

Cited by 45 publications

(62 citation statements)

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“…Grafts are either sutured to the epineurium of single nerves or more commonly to the perineurium of individual fascicles, depending on nerve calibre, type and location [30,63,74]. The interfascicular nerve graft was described by Millesi et al [75]. Vascularized nerve graft was designed by Taylor and Ham, whereby the donor nerve is transposed with its arterial and venous supply into the graft site [76].…”

Section: Nerve Graftsmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Section: Nerve Graftsmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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“…Gaps or scars are particularly complicated to repair as the regenerating axons face a gap between the injury and the target (which becomes more difficult to overcome the longer the distance). Interpositional nerve grafts are often used as a treatment for longer gaps or scar segments to provide a pathway for regenerating axons, while direct repair can be used for shorter areas of denervation (Millesi et al, 1972). Current strategies use cable grafting in most cases of facial paralysis when primary repair is not possible, using greater auricular, sural or medial and lateral antebrachial cutaneous nerves (Humphrey & Kreit, 2008).…”

Section: Treatmentmentioning

confidence: 99%

Stem Cells in Ophthalmology

Wester¹,

Goldberg²

2012

New Advances in Stem Cell Transplantation

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“…Colleagues at the same institute later transplanted kidneys in rats, and anastomosed divided oviducts in rabbits and ureters and vas deferens in dogs. These techniques were then applied to plastic and reconstructive surgery (Buncke & Schulz, 1965;Sixth People's Hospital, Shanghai, 1967), to peripheral nerve surgery (Kurze, 1964;Smith, 1964;Millesi, Meissl & Berger, 1972) and to experimental organ transplantation (Fisher, 1965). Neurosurgeons employed the microscope for dissections deep within the cranial vault to examine and treat cerebral aneurysms and tumours with minimal disturbance to critical cerebral blood supply (Donaghy & Yasargil, 1967).…”

Section: Historicalmentioning

confidence: 99%

Microsurgery in the clinic and laboratory

Green

1987

Lab Anim

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Laboratory animals have been crucial to the development of modern microsurgical techniques which are now routinely used in many clinical departments worldwide. In return, microsurgical techniques are important in biomedical research as they allow many surgical procedures to be performed on rodents instead of dogs, pigs or primates. This has obvious advantages in terms of low cost, the use of statistically valid numbers for comparison and the availability of genetically defined animals which are more likely to give valid answers to immunological questions. Microsurgical reconstruction is important in plastic, orthopaedic, urogenital, vascular and peripheral nerve surgery in man and it is likely that it will become part of every surgeon's training in the near future. In this review, the instrumentation essential to any microsurgical enterprise and the sutures available are described. Basic microsurgical techniques for end-to-end and end-to-side anastomosis of small vessels and for joining peripheral nerves, oviducts and other tubular structures are given in outline. Techniques for transplanting kidney, heart, heart and lung, liver, spleen, pancreas, small bowel, stomach, testicle, ovary and whole joint are only outlined but key references are given. Finally, some of the clinical indications for microsurgical reconstruction are reviewed.

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The interfascicular nerve-grafting of median and ulnar nerves

Cited by 45 publications

References 0 publications

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Stem Cells in Ophthalmology

Microsurgery in the clinic and laboratory

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