The interfacial, emulsification and encapsulation properties of hydrophobically modified inulin

Abstract

Octenyl- and dodecenyl succinic anhydride derivatives (OSA- and DDSA-) of inulin have been synthesised and their solution and interfacial properties have been determined and compared to a commercially available alkylated inulin, Inutec SP1. All samples formed micellar aggregates in solution above a critical concentration (critical aggregation concentration) and were able to 'dissolve' a hydrophobic dye. They were also able to form stable oil-in-water (O/W) emulsions as assessed by measurements of their droplet size as a function of time. DDSA-inulin with a high degree of substitution was found to be effective at encapsulating beta carotene using the solvent evaporation method which yielded a solid which dissolved readily in simulated gastric fluid. The results confirm the potential application of these materials in a number of areas including, drug delivery, pharmaceuticals, neutraceuticals, cosmetics and personal care.

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

“…The zeta potential of the OSA inulin derivative was observed to increase (-4.8 mV to -60.8 mV) with increasing pH (1.9 to 9.7), whereas that of the DDSA-inulin derivative was found to increase (2.2 mV–55.5 mV) within a pH range of 1.8–10.2. The results of droplet size as a function of time and temperature were assessed for the DDSA-inulin derivative, OSA inulin derivative, and Inutec®SP1, and it was observed that the DDSA-inulin derivative showed the greatest emulsification properties (smaller droplet size) of the three compounds ( Kokubun et al, 2018 ). The same research group studied the emulsification properties of OSA inulin derivatives and DDSA-inulin derivatives in the presence of electrolytes and during storage.…”

“…Inulin, which was discovered as a fructan-type oligosaccharide, is distributed in more than 36,000 vegetables and herbs. Jerusalem artichokes, leeks, oats, onion, and garlic are abundant sources of inulin, while it is obtained commercially from members of the Asteraceae family, such as chicory ( Afinjuomo et al, 2019 ; Kokubun, Ratcliffe, & Williams, 2018 ). Inulin is made up of d -fructose units that are linked by β-2,1 glycosidic bonds with a wide range of degrees of polymerization (between 2 and 60) and commonly combined with a glucose residue at the terminus ( López-Molina et al, 2015 ).…”

“…Moreover, various types of inulin derivatives have been produced by the reaction of inulin with fatty acid methyl esters (FAMEs), fatty acid chlorides, alkyl epoxides, and alkyl isocyanates ( Exerowa & Platikanov, 2009 ; Exerowa, Gotchev, Gotchev et al, 2009 Gotchev et al, 2011; Khristov & Czarnecki, 2010 ; Stevens, Meriggi, & Booten, 2001 , 2001b ). In consideration of environmental issues with the development of industrialization, a green methodology has been established to synthesize different types of inulin derivatives with varying alkenyl chain lengths and varying degrees of substitution (DSs) by using alkenyl succinic anhydrides in an aqueous environment under mild alkaline conditions ( Han, Ratcliffe, & Williams, 2015 ; Han, Ratcliffe, & Williams, 2017 ; Kokubun, Ratcliffe, & Williams, 2013 ; Kokubun, Ratcliffe, & Williams, 2015 ; Kokubun et al, 2018 ; Morros, Levecke, & Infante, 2010 ; Morros, Levecke, & Infante, 2011 ). It was revealed that these types of inulin derivatives adsorbed at the liquid-liquid interface, solid-liquid interface, and air-water interface and produced micellar-like structures in the solution above a critical concentration.…”

Construction of octenyl succinic anhydride modified porous starch for improving bioaccessibility of β-carotene in emulsions

“…It was found that availability of b-carotene enhanced along with the increasing DS of OSA modied starches, which was consistent with previous studies. 18,30,45 For example, 5% OSA@PS sample have the excellent bioaccessibility, due to the DS up to 0.0289. Compared with OSA@NS samples, the bioaccessibility of OSA@PS emulsions showed almost twice than that of OSA@NS.…”

Biodegradable super porous inulin cryogels as potential drug carrier

“…Additionally, inulin can be considered a renewable material in bioprocesses for biofuel production. The biocompatible, biodegradable, renewable, and hydrophilic structure, along with natural and plant‐based origin, make inulin a very attractive material for diverse applications 12‐14 …”