The interface reaction pattern in the skin: an integrated review of clinical and pathological features

Deschaine, Maria; Lehman, Julia S.

doi:10.1016/j.humpath.2019.06.004

Cited by 10 publications

(2 citation statements)

References 226 publications

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“…Mild tubular degeneration in the kidney was observed in 14 out of 46 specimens, similarly to findings by Noguera et al, (2008) Regarding some possible insights on the disease pathogenesis, our observations are in line with those reported by Ferguson et al, (2006). Skin lesions display aspects similar to the lichenoid dermatitis observed and described in humans and other mammals as a result of the T-cell-mediated or autoimmune response (Deschaine & Lehman, 2019;Gross et al, 2005). The strong presence of lymphocytes and macrophages, also reported by McCarthy et al, (2013) andvon Gersdorff Jørgensen et al, (2019), suggests an immunopathological mechanism promoting the development of these lesions.…”

Section: Discussionsupporting

confidence: 91%

Red mark syndrome of trout (Oncorhynchus mykiss; Walbaum, 1792): Histopathological scoring and correlation with gross lesions

Galeotti

Sarli

Sirri

et al. 2021

Journal of Fish Diseases

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Red mark syndrome (RMS) is a skin disorder affecting rainbow trout (Oncorhynchus mykiss). The present work aimed to correlate the gross skin lesions affecting 46 fish sampled from farms surveyed for RMS with their microscopic features, identifying histological parameters that may be suggestive of disease progression. Skin lesions were grossly included in one of three categories (types I, II and III) according to the progressive degree of severity. Histological parameters and anti‐proliferating cell nuclear antigen (PCNA) tissue immunoreactivity were semi‐quantitatively assessed. In the dermis, PCNA‐positive lymphocytes, fibroblasts and endothelial cells were indicative of active phlogosis. A significant increase in PCNA‐immunoreactive lymphocytes, from gross type I to type III cases, was found only in the hypodermis. The histological parameters significantly associated with the gross lesion severity were progressive loss of the epithelium and scales, recruitment of inflammatory cells in the stratum compactum, loss of architecture of the stratum compactum, perivascular and perineural granulomatous inflammation and increase in lymphocyte infiltration of the muscular layer. In the type II and type III categories, inflammation in the hypodermis and muscle displayed a granulomatous pattern, reinforcing the hypothesis of an immunopathological mechanism. The morphological diagnosis of “deep chronic dermatitis associated to panniculitis and myositis, characterised by lympho‐histiocytic and granulomatous reaction” is suggested.

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Section: Discussionsupporting

confidence: 91%

Red mark syndrome of trout (Oncorhynchus mykiss; Walbaum, 1792): Histopathological scoring and correlation with gross lesions

Galeotti

Sarli

Sirri

et al. 2021

Journal of Fish Diseases

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“…Brightfield and histological stains, such as hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS), are used extensively in pathology to assess tissue integrity, health, and disease. − Stained tissues have been employed with IMS to connect molecular profiles to histological features of both healthy and diseased tissue, such as cancer − and functional disorders. , Recently, Basu et al. enabled IMS and histology to be rapidly correlated by incorporating matrix precoated slides, templates, and a 10 kHz laser .…”

Section: Integration With Other Technologiesmentioning

confidence: 99%

Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine

Neumann

Djambazova

Caprioli

et al. 2020

J. Am. Soc. Mass Spectrom.

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Imaging mass spectrometry has become a mature molecular mapping technology that is used for molecular discovery in many medical and biological systems. While powerful by itself, imaging mass spectrometry can be complemented by the addition of other orthogonal, chemically informative imaging technologies to maximize the information gained from a single experiment and enable deeper understanding of biological processes. Within this review, we describe MALDI, SIMS, and DESI imaging mass spectrometric technologies and how these have been integrated with other analytical modalities such as microscopy, transcriptomics, spectroscopy, and electrochemistry in a field termed multimodal imaging. We explore the future of this field and discuss forthcoming developments that will bring new insights to help unravel the molecular complexities of biological systems, from single cells to functional tissue structures and organs.

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Patternanalyse entzündlicher Hauterkrankungen nach A. B. Ackerman – stets aktuell

Paredes

2020

Pathologe

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The interface reaction pattern in the skin: an integrated review of clinical and pathological features

Cited by 10 publications

References 226 publications

Red mark syndrome of trout (Oncorhynchus mykiss; Walbaum, 1792): Histopathological scoring and correlation with gross lesions

Red mark syndrome of trout (Oncorhynchus mykiss; Walbaum, 1792): Histopathological scoring and correlation with gross lesions

Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine

Patternanalyse entzündlicher Hauterkrankungen nach A. B. Ackerman – stets aktuell

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