The Interface of Pain and Mood Disturbances in the Rheumatic Diseases

Goldenberg, Don L.

doi:10.1016/j.semarthrit.2008.11.005

Cited by 91 publications

(66 citation statements)

References 228 publications

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“…Individuals with comorbid pain and depression experience higher morbidity and mortality relative to either condition alone (1)(2)(3)(4)(5)(6). In rheumatic conditions, pain of varying intensity and duration is one of the most significant symptoms for patients (7)(8)(9), and it has been estimated that 5-20% of patients have comorbid depression (5,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…In rheumatic conditions, pain of varying intensity and duration is one of the most significant symptoms for patients (7)(8)(9), and it has been estimated that 5-20% of patients have comorbid depression (5,10,11). In a population sample, Kessler et al (2003) (12) found that 45% of patients with arthritis had a comorbid mental disorder, twice that of patients without arthritis.…”

Section: Introductionmentioning

confidence: 99%

“…Role impairments associated with arthritis were largely confined to cases with comorbid mental disorders. Other studies have shown that pain and depression are more important predictors of disability and quality of life than radiographic joint damage and disease activity (5), and that arthritis patients with depression tend to be less compliant with treatment compared with arthritis patients without depression (6).…”

Section: Introductionmentioning

confidence: 99%

“…Several hypotheses have been formulated to explain the link between pain and depression (5,7,13,14). According to the consequence hypothesis, pain develops first; interferes with sleep, work, and social activities; and ultimately leads to an increased risk of depression.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Longitudinal study of the bidirectional association between pain and depressive symptoms in patients with psoriatic arthritis

Husted¹,

Tom²,

Farewell³

et al. 2012

Arthritis Care & Research

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Objective. To test the bidirectional hypothesis that depressive symptoms influence changes in pain over time, and pain influences changes in depressive symptoms. Methods. A total of 394 patients attending the University of Toronto Psoriatic Arthritis clinic were followed over a mean period of 7.5 years with annual assessments, including number of swollen joints (SJC), Health Assessment Questionnaire (HAQ), and the Medical Outcomes Survey Short Form 36 (SF-36). Linear mixed-effects models were used to examine the cross-and lagged associations between the changes in HAQ pain and in the SF-36 mental component summary (MCS) score, adjusting for SJC and other covariates. Results. The strongest predictors of changes in pain, SJC, and depressive symptoms between visits were scores of the corresponding variables at the previous visit, with standardized regression coefficients exceeding 0.75 in absolute value. There was, however, evidence of a small, but consequential, bidirectional relationship (i.e., standardized regression coefficients <0.3) between depressive symptoms and pain. Both previous MCS scores and change in MCS scores were associated with change in pain between visits; conversely, previous pain scores and change in pain scores were associated with change in depressive symptoms between visits. Conclusion. Even though cross-variable associations between pain and depressive symptoms exist, changes in pain and depressive symptoms appear to be strongly driven by their measurements at the previous visit. To optimize patient outcomes, a clinical approach that assesses and treats clinically significant depressive symptoms, as well as pain, is required.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal study of the bidirectional association between pain and depressive symptoms in patients with psoriatic arthritis

Husted¹,

Tom²,

Farewell³

et al. 2012

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…We used ICD-9-CM diagnostic codes 300.00-300.09, 300.20-300.29, and 300.3 to categorize anxiety; code 309.81 to categorize PTSD; and codes 296.20-296.25, 296.30-296.36, 300.4, and 311 to categorize depression diagnoses according to a previously published study of mental health diagnoses in the OIF/OEF/OND Veteran population [19]. These represent a cluster of mood and anxiety disorders that most prior FMS research has focused on [20][21], but it is not an exhaustive list. Others include conversion and bipolar disorder, which are not the focus of this current study [22][23].…”

Section: Mental Health Comorbiditiesmentioning

confidence: 99%

Fibromyalgia syndrome care of Iraq- and Afghanistan-deployed Veterans in Veterans Health Administration

et al. 2016

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Abstract-Little is known regarding fibromyalgia syndrome (FMS) care among Operation Iraqi Freedom/Operation Enduring Freedom/Operation New Dawn (OIF/OEF/OND) Veterans. Current recommendations include interdisciplinary, teambased combined care approaches and limited opioid use. In this study of OIF/OEF/OND Veterans who accessed Veterans Health Administration services between 2002 and 2012, we hypothesized that combined care (defined as at least 4 primary care visits/yr with visits to mental health and/or rheumatology) versus <4 primary care visits/yr only would be associated with lower risk of at least 2 opioid prescriptions 12 mo following an FMS diagnosis. Using generalized linear models with a loglink, the Poisson family, and robust standard errors, we estimated risk ratios (RRs) and 95% confidence intervals (CIs). We found that 1% of Veterans had at least 2 FMS diagnoses (International Classification of Diseases-9th Revision-Clinical Modification code 729.1) or at least 1 FMS diagnosis by rheumatology. Veterans with (vs without) FMS were more likely to be female, older, Hispanic, and never/currently married. Combined primary, mental health, and rheumatology care was associated with at least 2 opioid prescriptions (RR [95% CI] for males 2.2 [1.1-4.4] and females 2. 8 [0.4-18.6]). Also, combined care was associated with at least 2 nonopioid painrelated prescriptions, a practice supported by evidence-based clinical practice guidelines. In tandem, these results provide mixed evidence of benefit of combined care for FMS. Future studies of healthcare encounter characteristics, care coordination, and benefits for Veterans with FMS are needed.

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