The interface between ecology, evolution, and cancer: More than ever a relevant research direction for both oncologists and ecologists

Thomas, Fréderic; Roche, Benjamín; Giraudeau, Mathieu; Hamede, Rodrigo; Újvári, Beáta

doi:10.1111/eva.13031

Cited by 10 publications

(8 citation statements)

References 49 publications

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“…Intratumor heterogeneity (ITH) is a constant in malignant neoplasms and the factor responsible for most therapeutic failures in clinical practice. Recent advances provided by massive genomic sequencing are showing the real scale and variability of spatial and temporal evolutionary patterns in many tumors [1][2][3]. Tumor evolution was initially considered to be a stochastic process, but some deterministic pathways correlating with prognosis have been identified recently [4].…”

Section: Significancementioning

confidence: 99%

Effects of heterogeneity on cancer: a game theory perspective

Laruelle¹,

Rocha²,

Manini³

et al. 2022

Preprint

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In this study, we explore interactions between cancer cells by using the hawk-dove game. We analyze the heterogeneity of tumors by considering games with populations composed of 2 or 3 types of cells. We determine what strategies are evolutionarily stable in the 2-type and 3-type population games and the corresponding expected payoffs. Our results show that the payoff of the best-off cell in the 2-type population game is higher than that of the best-off cell in the 3-type population game. Translating these mathematical findings to the field of oncology suggests that a branching-type tumor pursues a less aggressive course than a punctuated-type one. Some histological and genomic data of clear cell renal cell carcinomas are consistent with these results.

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Section: Significancementioning

confidence: 99%

Effects of heterogeneity on cancer: a game theory perspective

Laruelle¹,

Rocha²,

Manini³

et al. 2022

Preprint

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show abstract

“…This has led some authors to suggest that deciphering cancer’s secrets is more than a pure technological problem and that cancer should be also thought of as a sort of social dysfunction 3 . This approach opens up promising new prospects for envisaging the evolutionary dynamics of tumors under ecological principles 4 , 5 .…”

Section: Ecologymentioning

confidence: 99%

Ecology and games in cancer: new insights into the disease

Manini

López

2022

Pathologica

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“…Recognition of the relative autonomy and evolvability of somatic cells opens a framework in which the concepts of habitat, diversity, niche, and population structure are key aspects of normal physiology [63,65]. So far considered mostly in the context of cancer [66][67][68], this eco-evolutionary perspective can be expanded also to capture the activity of cells in a healthy organism. Reconceptualizing certain forms of collective cell behavior as equivalent to that of a flock of birds or school of fish such a perspective could help to explain cell coordination in populational terms rather than in top-down regulation categories [64].…”

Section: Individuals As Collectivesmentioning

confidence: 99%

Struggle within: evolution and ecology of somatic cell populations

Świątczak

2021

Cell. Mol. Life Sci.

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The extent to which normal (nonmalignant) cells of the body can evolve through mutation and selection during the lifetime of the organism has been a major unresolved issue in evolutionary and developmental studies. On the one hand, stable multicellular individuality seems to depend on genetic homogeneity and suppression of evolutionary conflicts at the cellular level. On the other hand, the example of clonal selection of lymphocytes indicates that certain forms of somatic mutation and selection are concordant with the organism-level fitness. Recent DNA sequencing and tissue physiology studies suggest that in addition to adaptive immune cells also neurons, epithelial cells, epidermal cells, hematopoietic stem cells and functional cells in solid bodily organs are subject to evolutionary forces during the lifetime of an organism. Here we refer to these recent studies and suggest that the expanding list of somatically evolving cells modifies idealized views of biological individuals as radically different from collectives.

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The interface between ecology, evolution, and cancer: More than ever a relevant research direction for both oncologists and ecologists

Cited by 10 publications

References 49 publications

Effects of heterogeneity on cancer: a game theory perspective

Effects of heterogeneity on cancer: a game theory perspective

Ecology and games in cancer: new insights into the disease

Struggle within: evolution and ecology of somatic cell populations

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